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Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.
Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R. Agarwal N, et al. Among authors: mackie k. Nat Neurosci. 2007 Jul;10(7):870-9. doi: 10.1038/nn1916. Epub 2007 Jun 10. Nat Neurosci. 2007. PMID: 17558404 Free PMC article.
CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.
Rajesh M, Mukhopadhyay P, Bátkai S, Haskó G, Liaudet L, Huffman JW, Csiszar A, Ungvari Z, Mackie K, Chatterjee S, Pacher P. Rajesh M, et al. Among authors: mackie k. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2210-8. doi: 10.1152/ajpheart.00688.2007. Epub 2007 Jul 27. Am J Physiol Heart Circ Physiol. 2007. PMID: 17660390 Free PMC article.
480 results