Chan LK - Search Results

1

Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.

Ko FC, Chan LK, Tung EK, Lowe SW, Ng IO, Yam JW. Ko FC, et al. Among authors: chan lk. Gastroenterology. 2010 Oct;139(4):1397-407. doi: 10.1053/j.gastro.2010.06.051. Epub 2010 Jun 20. Gastroenterology. 2010. PMID: 20600027 Free article.

2

Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.

Wong CC, Wong CM, Ko FC, Chan LK, Ching YP, Yam JW, Ng IO. Wong CC, et al. Among authors: chan lk. PLoS One. 2008 Jul 23;3(7):e2779. doi: 10.1371/journal.pone.0002779. PLoS One. 2008. PMID: 18648664 Free PMC article.

3

Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function.

Chan LK, Ko FC, Ng IO, Yam JW. Chan LK, et al. PLoS One. 2009;4(5):e5572. doi: 10.1371/journal.pone.0005572. Epub 2009 May 15. PLoS One. 2009. PMID: 19440389 Free PMC article.

4

Deleted in liver cancer 1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation in hepatocellular carcinoma.

Ko FC, Yeung YS, Wong CM, Chan LK, Poon RT, Ng IO, Yam JW. Ko FC, et al. Among authors: chan lk. Liver Int. 2010 Jan;30(1):139-48. doi: 10.1111/j.1478-3231.2009.02133.x. Epub 2009 Oct 27. Liver Int. 2010. PMID: 19874489

5

Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway.

Leung TH, Yam JW, Chan LK, Ching YP, Ng IO. Leung TH, et al. Among authors: chan lk. Liver Int. 2010 Oct;30(9):1315-23. doi: 10.1111/j.1478-3231.2010.02307.x. Liver Int. 2010. PMID: 20629949

6

Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo.

Chan LK, Ko FC, Sze KM, Ng IO, Yam JW. Chan LK, et al. PLoS One. 2011;6(9):e25547. doi: 10.1371/journal.pone.0025547. Epub 2011 Sep 26. PLoS One. 2011. PMID: 21966542 Free PMC article.

7

Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis.

Tse EY, Ko FC, Tung EK, Chan LK, Lee TK, Ngan ES, Man K, Wong AS, Ng IO, Yam JW. Tse EY, et al. Among authors: chan lk. J Pathol. 2012 Mar;226(4):645-53. doi: 10.1002/path.3957. Epub 2012 Jan 4. J Pathol. 2012. PMID: 22072235

8

PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.

Ko FC, Chan LK, Sze KM, Yeung YS, Tse EY, Lu P, Yu MH, Ng IO, Yam JW. Ko FC, et al. Among authors: chan lk. Nat Commun. 2013;4:1618. doi: 10.1038/ncomms2604. Nat Commun. 2013. PMID: 23511482 Free article.

9

Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma.

Chan LK, Chiu YT, Sze KM, Ng IO. Chan LK, et al. Oncotarget. 2015 Aug 28;6(25):20964-76. doi: 10.18632/oncotarget.4122. Oncotarget. 2015. PMID: 26035355 Free PMC article.

10

Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma.

Kai AK, Chan LK, Lo RC, Lee JM, Wong CC, Wong JC, Ng IO. Kai AK, et al. Among authors: chan lk. Hepatology. 2016 Aug;64(2):473-87. doi: 10.1002/hep.28577. Epub 2016 Apr 30. Hepatology. 2016. PMID: 27018975 Free PMC article.

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