Harris ME - Search Results

1

Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base.

Harris ME, Dai Q, Gu H, Kellerman DL, Piccirilli JA, Anderson VE. Harris ME, et al. J Am Chem Soc. 2010 Aug 25;132(33):11613-21. doi: 10.1021/ja103550e. J Am Chem Soc. 2010. PMID: 20669950 Free PMC article.

2

Pre-steady-state and stopped-flow fluorescence analysis of Escherichia coli ribonuclease III: insights into mechanism and conformational changes associated with binding and catalysis.

Campbell FE Jr, Cassano AG, Anderson VE, Harris ME. Campbell FE Jr, et al. Among authors: harris me. J Mol Biol. 2002 Mar 15;317(1):21-40. doi: 10.1006/jmbi.2002.5413. J Mol Biol. 2002. PMID: 11916377

3

Evidence for direct attack by hydroxide in phosphodiester hydrolysis.

Cassano AG, Anderson VE, Harris ME. Cassano AG, et al. Among authors: harris me. J Am Chem Soc. 2002 Sep 18;124(37):10964-5. doi: 10.1021/ja020823j. J Am Chem Soc. 2002. PMID: 12224928

4

Understanding the transition states of phosphodiester bond cleavage: insights from heavy atom isotope effects.

Cassano AG, Anderson VE, Harris ME. Cassano AG, et al. Among authors: harris me. Biopolymers. 2004 Jan;73(1):110-29. doi: 10.1002/bip.10517. Biopolymers. 2004. PMID: 14691944 Review.

5

Analysis of solvent nucleophile isotope effects: evidence for concerted mechanisms and nucleophilic activation by metal coordination in nonenzymatic and ribozyme-catalyzed phosphodiester hydrolysis.

Cassano AG, Anderson VE, Harris ME. Cassano AG, et al. Among authors: harris me. Biochemistry. 2004 Aug 17;43(32):10547-59. doi: 10.1021/bi049188f. Biochemistry. 2004. PMID: 15301552

6

RNA-dependent folding and stabilization of C5 protein during assembly of the E. coli RNase P holoenzyme.

Guo X, Campbell FE, Sun L, Christian EL, Anderson VE, Harris ME. Guo X, et al. Among authors: harris me. J Mol Biol. 2006 Jun 30;360(1):190-203. doi: 10.1016/j.jmb.2006.05.001. Epub 2006 May 15. J Mol Biol. 2006. PMID: 16750220

7

Activation of oxygen nucleophiles in enzyme catalysis.

Anderson VE, Ruszczycky MW, Harris ME. Anderson VE, et al. Among authors: harris me. Chem Rev. 2006 Aug;106(8):3236-51. doi: 10.1021/cr050281z. Chem Rev. 2006. PMID: 16895326 Review. No abstract available.

8

Inaccuracies in selected ion monitoring determination of isotope ratios obviated by profile acquisition: nucleotide 18O/16O measurements.

Cassano AG, Wang B, Anderson DR, Previs S, Harris ME, Anderson VE. Cassano AG, et al. Among authors: harris me. Anal Biochem. 2007 Aug 1;367(1):28-39. doi: 10.1016/j.ab.2007.03.037. Epub 2007 Apr 2. Anal Biochem. 2007. PMID: 17560863 Free PMC article.

9

Efficient synthesis of [2'-18O]uridine and its incorporation into oligonucleotides: a new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis.

Dai Q, Frederiksen JK, Anderson VE, Harris ME, Piccirilli JA. Dai Q, et al. Among authors: harris me. J Org Chem. 2008 Jan 4;73(1):309-11. doi: 10.1021/jo701727h. Epub 2007 Dec 4. J Org Chem. 2008. PMID: 18052189

10

Experimental analyses of the chemical dynamics of ribozyme catalysis.

Harris ME, Cassano AG. Harris ME, et al. Curr Opin Chem Biol. 2008 Dec;12(6):626-39. doi: 10.1016/j.cbpa.2008.10.005. Epub 2008 Oct 24. Curr Opin Chem Biol. 2008. PMID: 18952193 Free PMC article. Review.

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