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Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.
Richter L, Munter LM, Ness J, Hildebrand PW, Dasari M, Unterreitmeier S, Bulic B, Beyermann M, Gust R, Reif B, Weggen S, Langosch D, Multhaup G. Richter L, et al. Among authors: langosch d. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. doi: 10.1073/pnas.1003026107. Epub 2010 Aug 2. Proc Natl Acad Sci U S A. 2010. PMID: 20679249 Free PMC article.
De novo design of conformationally flexible transmembrane peptides driving membrane fusion.
Hofmann MW, Weise K, Ollesch J, Agrawal P, Stalz H, Stelzer W, Hulsbergen F, de Groot H, Gerwert K, Reed J, Langosch D. Hofmann MW, et al. Among authors: langosch d. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14776-81. doi: 10.1073/pnas.0405175101. Epub 2004 Sep 29. Proc Natl Acad Sci U S A. 2004. PMID: 15456911 Free PMC article.
Tryptophan supports interaction of transmembrane helices.
Ridder A, Skupjen P, Unterreitmeier S, Langosch D. Ridder A, et al. Among authors: langosch d. J Mol Biol. 2005 Dec 9;354(4):894-902. doi: 10.1016/j.jmb.2005.09.084. Epub 2005 Oct 21. J Mol Biol. 2005. PMID: 16280130
The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.
Pester O, Barrett PJ, Hornburg D, Hornburg P, Pröbstle R, Widmaier S, Kutzner C, Dürrbaum M, Kapurniotu A, Sanders CR, Scharnagl C, Langosch D. Pester O, et al. Among authors: langosch d. J Am Chem Soc. 2013 Jan 30;135(4):1317-29. doi: 10.1021/ja3112093. Epub 2013 Jan 16. J Am Chem Soc. 2013. PMID: 23265086 Free PMC article.
112 results