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Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation.
Bruno T, Desantis A, Bossi G, Di Agostino S, Sorino C, De Nicola F, Iezzi S, Franchitto A, Benassi B, Galanti S, La Rosa F, Floridi A, Bellacosa A, Passananti C, Blandino G, Fanciulli M. Bruno T, et al. Among authors: de nicola f. Cancer Cell. 2010 Aug 9;18(2):122-34. doi: 10.1016/j.ccr.2010.05.027. Cancer Cell. 2010. PMID: 20708154 Free article.
Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb.
Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M. Bruno T, et al. Among authors: de angelis r, de nicola f. Cancer Cell. 2002 Nov;2(5):387-99. doi: 10.1016/s1535-6108(02)00182-4. Cancer Cell. 2002. PMID: 12450794 Free article.
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.
Bruno T, De Nicola F, Iezzi S, Lecis D, D'Angelo C, Di Padova M, Corbi N, Dimiziani L, Zannini L, Jekimovs C, Scarsella M, Porrello A, Chersi A, Crescenzi M, Leonetti C, Khanna KK, Soddu S, Floridi A, Passananti C, Delia D, Fanciulli M. Bruno T, et al. Among authors: de nicola f. Cancer Cell. 2006 Dec;10(6):473-86. doi: 10.1016/j.ccr.2006.10.012. Cancer Cell. 2006. PMID: 17157788 Free article.
Che-1 activates XIAP expression in response to DNA damage.
Bruno T, Iezzi S, De Nicola F, Di Padova M, Desantis A, Scarsella M, Di Certo MG, Leonetti C, Floridi A, Passananti C, Fanciulli M. Bruno T, et al. Among authors: de nicola f. Cell Death Differ. 2008 Mar;15(3):515-20. doi: 10.1038/sj.cdd.4402284. Epub 2007 Nov 30. Cell Death Differ. 2008. PMID: 18049476
Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas.
Botti E, Spallone G, Moretti F, Marinari B, Pinetti V, Galanti S, De Meo PD, De Nicola F, Ganci F, Castrignanò T, Pesole G, Chimenti S, Guerrini L, Fanciulli M, Blandino G, Karin M, Costanzo A. Botti E, et al. Among authors: de meo pd, de nicola f. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13710-5. doi: 10.1073/pnas.1110931108. Epub 2011 Aug 1. Proc Natl Acad Sci U S A. 2011. PMID: 21807998 Free PMC article.
Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization.
Sorino C, Bruno T, Desantis A, Di Certo MG, Iezzi S, De Nicola F, Catena V, Floridi A, Chessa L, Passananti C, Cundari E, Fanciulli M. Sorino C, et al. Among authors: de nicola f. J Biol Chem. 2013 Aug 9;288(32):23348-57. doi: 10.1074/jbc.M113.465302. Epub 2013 Jun 24. J Biol Chem. 2013. PMID: 23798705 Free PMC article.
102 results