Kozielski F - Search Results

1

Structure-activity relationships and molecular docking of novel dihydropyrimidine-based mitotic Eg5 inhibitors.

Prokopcová H, Dallinger D, Uray G, Kaan HY, Ulaganathan V, Kozielski F, Laggner C, Kappe CO. Prokopcová H, et al. Among authors: kozielski f. ChemMedChem. 2010 Oct 4;5(10):1760-9. doi: 10.1002/cmdc.201000252. ChemMedChem. 2010. PMID: 20737530

2

Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.

Kaan HY, Ulaganathan V, Rath O, Prokopcová H, Dallinger D, Kappe CO, Kozielski F. Kaan HY, et al. Among authors: kozielski f. J Med Chem. 2010 Aug 12;53(15):5676-83. doi: 10.1021/jm100421n. J Med Chem. 2010. PMID: 20597485

3

Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.

Kaan HY, Weiss J, Menger D, Ulaganathan V, Tkocz K, Laggner C, Popowycz F, Joseph B, Kozielski F. Kaan HY, et al. Among authors: kozielski f. J Med Chem. 2011 Mar 24;54(6):1576-86. doi: 10.1021/jm100991m. Epub 2011 Feb 23. J Med Chem. 2011. PMID: 21344920

4

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

Debonis S, Skoufias DA, Indorato RL, Liger F, Marquet B, Laggner C, Joseph B, Kozielski F. Debonis S, et al. Among authors: kozielski f. J Med Chem. 2008 Mar 13;51(5):1115-25. doi: 10.1021/jm070606z. Epub 2008 Feb 12. J Med Chem. 2008. PMID: 18266314

5

An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex.

Kaan HY, Ulaganathan V, Hackney DD, Kozielski F. Kaan HY, et al. Among authors: kozielski f. Biochem J. 2009 Dec 14;425(1):55-60. doi: 10.1042/BJ20091207. Biochem J. 2009. PMID: 19793049

6

Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.

Wang F, Good JA, Rath O, Kaan HY, Sutcliffe OB, Mackay SP, Kozielski F. Wang F, et al. Among authors: kozielski f. J Med Chem. 2012 Feb 23;55(4):1511-25. doi: 10.1021/jm201195m. Epub 2012 Feb 13. J Med Chem. 2012. PMID: 22248262 Free PMC article.

7

"Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5.

Kaan HY, Major J, Tkocz K, Kozielski F, Rosenfeld SS. Kaan HY, et al. Among authors: kozielski f. J Biol Chem. 2013 Jun 21;288(25):18588-98. doi: 10.1074/jbc.M113.462648. Epub 2013 May 8. J Biol Chem. 2013. PMID: 23658017 Free PMC article.

8

The structure of the kinesin-1 motor-tail complex reveals the mechanism of autoinhibition.

Kaan HY, Hackney DD, Kozielski F. Kaan HY, et al. Among authors: kozielski f. Science. 2011 Aug 12;333(6044):883-5. doi: 10.1126/science.1204824. Science. 2011. PMID: 21836017 Free PMC article.

9

Structural insights into a unique inhibitor binding pocket in kinesin spindle protein.

Ulaganathan V, Talapatra SK, Rath O, Pannifer A, Hackney DD, Kozielski F. Ulaganathan V, et al. Among authors: kozielski f. J Am Chem Soc. 2013 Feb 13;135(6):2263-72. doi: 10.1021/ja310377d. Epub 2013 Feb 4. J Am Chem Soc. 2013. PMID: 23305346

10

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

Good JA, Wang F, Rath O, Kaan HY, Talapatra SK, Podgórski D, MacKay SP, Kozielski F. Good JA, et al. Among authors: kozielski f. J Med Chem. 2013 Mar 14;56(5):1878-93. doi: 10.1021/jm3014597. Epub 2013 Feb 27. J Med Chem. 2013. PMID: 23394180 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

80 results

Search Page

Filters