Jiracek J - Search Results

1

Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.

Strakova J, Williams KT, Gupta S, Schalinske KL, Kruger WD, Rozen R, Jiracek J, Li L, Garrow TA. Strakova J, et al. Among authors: jiracek j. Nutr Res. 2010 Jul;30(7):492-500. doi: 10.1016/j.nutres.2010.06.017. Nutr Res. 2010. PMID: 20797482 Free PMC article.

2

Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice.

Collinsova M, Strakova J, Jiracek J, Garrow TA. Collinsova M, et al. Among authors: jiracek j. J Nutr. 2006 Jun;136(6):1493-7. doi: 10.1093/jn/136.6.1493. J Nutr. 2006. PMID: 16702310 Free article.

3

Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis.

Castro C, Gratson AA, Evans JC, Jiracek J, Collinsová M, Ludwig ML, Garrow TA. Castro C, et al. Among authors: jiracek j. Biochemistry. 2004 May 11;43(18):5341-51. doi: 10.1021/bi049821x. Biochemistry. 2004. PMID: 15122900

4

S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase.

Jiracek J, Collinsova M, Rosenberg I, Budesinsky M, Protivinska E, Netusilova H, Garrow TA. Jiracek J, et al. J Med Chem. 2006 Jun 29;49(13):3982-9. doi: 10.1021/jm050885v. J Med Chem. 2006. PMID: 16789755 Free PMC article.

5

Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase.

Vanek V, Budesínský M, Kabeleová P, Sanda M, Kozísek M, Hanclová I, Mládková J, Brynda J, Rosenberg I, Koutmos M, Garrow TA, Jirácek J. Vanek V, et al. Among authors: jiracek j. J Med Chem. 2009 Jun 25;52(12):3652-65. doi: 10.1021/jm8015798. J Med Chem. 2009. PMID: 19534555 Free PMC article.

6

The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase.

Pícha J, Vaněk V, Buděšínský M, Mládková J, Garrow TA, Jiráček J. Pícha J, et al. Among authors: jiracek j. Eur J Med Chem. 2013 Jul;65:256-75. doi: 10.1016/j.ejmech.2013.04.039. Epub 2013 Apr 30. Eur J Med Chem. 2013. PMID: 23727536

7

Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2.

Mládková J, Vaněk V, Buděšínský M, Elbert T, Demianová Z, Garrow TA, Jiráček J. Mládková J, et al. Among authors: jiracek j. J Med Chem. 2012 Aug 9;55(15):6822-31. doi: 10.1021/jm300571h. Epub 2012 Jul 18. J Med Chem. 2012. PMID: 22775318

8

Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase.

Collinsová M, Castro C, Garrow TA, Yiotakis A, Dive V, Jirácek J. Collinsová M, et al. Among authors: jiracek j. Chem Biol. 2003 Feb;10(2):113-22. doi: 10.1016/s1074-5521(03)00008-5. Chem Biol. 2003. PMID: 12618183

9

Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase.

Mládková J, Hladílková J, Diamond CE, Tryon K, Yamada K, Garrow TA, Jungwirth P, Koutmos M, Jiráček J. Mládková J, et al. Among authors: jiracek j. Proteins. 2014 Oct;82(10):2552-64. doi: 10.1002/prot.24619. Epub 2014 Jun 17. Proteins. 2014. PMID: 24895213

10

Betaine-homocysteine methyltransferase: zinc in a distorted barrel.

Evans JC, Huddler DP, Jiracek J, Castro C, Millian NS, Garrow TA, Ludwig ML. Evans JC, et al. Among authors: jiracek j. Structure. 2002 Sep;10(9):1159-71. doi: 10.1016/s0969-2126(02)00796-7. Structure. 2002. PMID: 12220488 Free article.

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