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Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.
Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Hutchinson MR, et al. Among authors: loram lc. Neuroscience. 2010 Jun 30;168(2):551-63. doi: 10.1016/j.neuroscience.2010.03.067. Epub 2010 Apr 8. Neuroscience. 2010. PMID: 20381591 Free PMC article.
Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, Maslanik T, Chapman TR, Strand KA, Fleshner M, Bachtell RK, Somogyi AA, Yin H, Katz JL, Rice KC, Maier SF, Watkins LR. Hutchinson MR, et al. Among authors: loram lc. J Neurosci. 2012 Aug 15;32(33):11187-200. doi: 10.1523/JNEUROSCI.0684-12.2012. J Neurosci. 2012. PMID: 22895704 Free PMC article.
Morphine activates neuroinflammation in a manner parallel to endotoxin.
Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K, Reddy A, Somogyi AA, Hutchinson MR, Watkins LR, Yin H. Wang X, et al. Among authors: loram lc. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6325-30. doi: 10.1073/pnas.1200130109. Epub 2012 Apr 2. Proc Natl Acad Sci U S A. 2012. PMID: 22474354 Free PMC article.
Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats.
Loram LC, Harrison JA, Chao L, Taylor FR, Reddy A, Travis CL, Giffard R, Al-Abed Y, Tracey K, Maier SF, Watkins LR. Loram LC, et al. Brain Behav Immun. 2010 Aug;24(6):959-67. doi: 10.1016/j.bbi.2010.03.008. Epub 2010 Mar 28. Brain Behav Immun. 2010. PMID: 20353818 Free PMC article.
38 results