Lee E - Search Results

1

sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair.

Alfaro MP, Vincent A, Saraswati S, Thorne CA, Hong CC, Lee E, Young PP. Alfaro MP, et al. Among authors: lee e. J Biol Chem. 2010 Nov 12;285(46):35645-53. doi: 10.1074/jbc.M110.135335. Epub 2010 Sep 7. J Biol Chem. 2010. PMID: 20826809 Free PMC article.

2

Lrp6 is required for convergent extension during Xenopus gastrulation.

Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E. Tahinci E, et al. Among authors: lee la, lee e. Development. 2007 Nov;134(22):4095-106. doi: 10.1242/dev.010272. Development. 2007. PMID: 17965054 Free PMC article.

3

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.

Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E. Cselenyi CS, et al. Among authors: lee la, lee e. Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8032-7. doi: 10.1073/pnas.0803025105. Epub 2008 May 28. Proc Natl Acad Sci U S A. 2008. PMID: 18509060 Free PMC article.

4

The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair.

Alfaro MP, Pagni M, Vincent A, Atkinson J, Hill MF, Cates J, Davidson JM, Rottman J, Lee E, Young PP. Alfaro MP, et al. Among authors: lee e. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18366-71. doi: 10.1073/pnas.0803437105. Epub 2008 Nov 18. Proc Natl Acad Sci U S A. 2008. PMID: 19017790 Free PMC article.

5

Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.

Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E. Jernigan KK, et al. Among authors: lee la, lee e. Sci Signal. 2010 May 11;3(121):ra37. doi: 10.1126/scisignal.2000647. Sci Signal. 2010. PMID: 20460648 Free PMC article.

6

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.

Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM 3rd, Lee E. Thorne CA, et al. Among authors: lee la, lee e. Nat Chem Biol. 2010 Nov;6(11):829-36. doi: 10.1038/nchembio.453. Epub 2010 Oct 3. Nat Chem Biol. 2010. PMID: 20890287 Free PMC article.

7

Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling.

Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E, Young PP. Saraswati S, et al. Among authors: lee e. PLoS One. 2010 Nov 29;5(11):e15521. doi: 10.1371/journal.pone.0015521. PLoS One. 2010. PMID: 21170416 Free PMC article.

8

A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts.

Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E. Thorne CA, et al. Among authors: lee la, lee e. J Biomol Screen. 2011 Oct;16(9):995-1006. doi: 10.1177/1087057111416657. Epub 2011 Aug 21. J Biomol Screen. 2011. PMID: 21859680 Free PMC article.

9

Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling.

Ni TT, Rellinger EJ, Mukherjee A, Xie S, Stephens L, Thorne CA, Kim K, Hu J, Lee E, Marnett L, Hatzopoulos AK, Zhong TP. Ni TT, et al. Among authors: lee e. Chem Biol. 2011 Dec 23;18(12):1658-68. doi: 10.1016/j.chembiol.2011.09.015. Chem Biol. 2011. PMID: 22195568 Free PMC article.

10

Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs.

Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E. Hang BI, et al. Among authors: lee la, lee e. Bioorg Med Chem. 2012 Mar 15;20(6):1869-77. doi: 10.1016/j.bmc.2011.12.044. Epub 2011 Dec 30. Bioorg Med Chem. 2012. PMID: 22261025 Free PMC article. Review.

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