Bardelle C - Search Results

1

Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors.

Bardelle C, Barlaam B, Brooks N, Coleman T, Cross D, Ducray R, Green I, Brempt CL, Olivier A, Read J. Bardelle C, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6242-5. doi: 10.1016/j.bmcl.2010.08.100. Epub 2010 Sep 16. Bioorg Med Chem Lett. 2010. PMID: 20850301

2

Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines.

Bardelle C, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ. Bardelle C, et al. Bioorg Med Chem Lett. 2008 May 1;18(9):2776-80. doi: 10.1016/j.bmcl.2008.04.015. Epub 2008 Apr 10. Bioorg Med Chem Lett. 2008. PMID: 18434142

3

Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines.

Bardelle C, Coleman T, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ. Bardelle C, et al. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5717-21. doi: 10.1016/j.bmcl.2008.09.087. Epub 2008 Sep 27. Bioorg Med Chem Lett. 2008. PMID: 18851911

4

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series.

Barlaam B, Ducray R, Lambert-van der Brempt C, Plé P, Bardelle C, Brooks N, Coleman T, Cross D, Kettle JG, Read J. Barlaam B, et al. Among authors: bardelle c. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2207-11. doi: 10.1016/j.bmcl.2011.03.009. Bioorg Med Chem Lett. 2011. PMID: 21441027

5

The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approach.

Allen JV, Bardelle C, Blades K, Buttar D, Chapman L, Colclough N, Dossetter AG, Garner AP, Girdwood A, Lambert C, Leach AG, Law B, Major J, Plant H, Slater AM. Allen JV, et al. Among authors: bardelle c. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5224-9. doi: 10.1016/j.bmcl.2011.07.047. Epub 2011 Jul 23. Bioorg Med Chem Lett. 2011. PMID: 21835616

6

Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.

Kettle JG, Ballard P, Bardelle C, Cockerill M, Colclough N, Critchlow SE, Debreczeni J, Fairley G, Fillery S, Graham MA, Goodwin L, Guichard S, Hudson K, Ward RA, Whittaker D. Kettle JG, et al. Among authors: bardelle c. J Med Chem. 2015 Mar 26;58(6):2834-44. doi: 10.1021/acs.jmedchem.5b00098. Epub 2015 Mar 12. J Med Chem. 2015. PMID: 25738750

7

Drug discovery for epigenetics targets.

Holdgate GA, Bardelle C, Lanne A, Read J, O'Donovan DH, Smith JM, Selmi N, Sheppard R. Holdgate GA, et al. Among authors: bardelle c. Drug Discov Today. 2022 Apr;27(4):1088-1098. doi: 10.1016/j.drudis.2021.10.020. Epub 2021 Oct 30. Drug Discov Today. 2022. PMID: 34728375 Review.

8

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.

Winter-Holt JJ, Bardelle C, Chiarparin E, Dale IL, Davey PRJ, Davies NL, Denz C, Fillery SM, Guérot CM, Han F, Hughes SJ, Kulkarni M, Liu Z, Milbradt A, Moss TA, Niu H, Patel J, Rabow AA, Schimpl M, Shi J, Sun D, Yang D, Guichard S. Winter-Holt JJ, et al. Among authors: bardelle c. J Med Chem. 2022 Feb 24;65(4):3306-3331. doi: 10.1021/acs.jmedchem.1c01871. Epub 2022 Feb 8. J Med Chem. 2022. PMID: 35133824

9

ATM Kinase Inhibitors: HTS Cellular Imaging Assay Using Cellomics™ ArrayScan VTI Platform.

Bardelle C, Boros J. Bardelle C, et al. Methods Mol Biol. 2017;1599:57-70. doi: 10.1007/978-1-4939-6955-5_5. Methods Mol Biol. 2017. PMID: 28477111

10

Development of a high-content high-throughput screening assay for the discovery of ATM signaling inhibitors.

Bardelle C, Boros J. Bardelle C, et al. J Biomol Screen. 2012 Aug;17(7):912-20. doi: 10.1177/1087057112448529. Epub 2012 May 31. J Biomol Screen. 2012. PMID: 22653913

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