Bissantz C - Search Results

1

Rational design of novel pyrrolidine derivatives as orally active neurokinin-3 receptor antagonists.

Ratni H, Ballard TM, Bissantz C, Hoffmann T, Jablonski P, Knoflach F, Knust H, Malherbe P, Nettekoven M, Patiny-Adam A, Riemer C, Schmitt M, Spooren W. Ratni H, et al. Among authors: bissantz c. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6735-8. doi: 10.1016/j.bmcl.2010.08.138. Epub 2010 Sep 17. Bioorg Med Chem Lett. 2010. PMID: 20850972

2

From astemizole to a novel hit series of small-molecule somatostatin 5 receptor antagonists via GPCR affinity profiling.

Guba W, Green LG, Martin RE, Roche O, Kratochwil N, Mauser H, Bissantz C, Christ A, Stahl M. Guba W, et al. Among authors: bissantz c. J Med Chem. 2007 Dec 13;50(25):6295-8. doi: 10.1021/jm701144e. Epub 2007 Nov 19. J Med Chem. 2007. PMID: 18020391

3

Me-talnetant and osanetant interact within overlapping but not identical binding pockets in the human tachykinin neurokinin 3 receptor transmembrane domains.

Malherbe P, Bissantz C, Marcuz A, Kratzeisen C, Zenner MT, Wettstein JG, Ratni H, Riemer C, Spooren W. Malherbe P, et al. Among authors: bissantz c. Mol Pharmacol. 2008 Jun;73(6):1736-50. doi: 10.1124/mol.107.042754. Epub 2008 Feb 28. Mol Pharmacol. 2008. PMID: 18308898

4

Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures.

Malherbe P, Kratzeisen C, Marcuz A, Zenner MT, Nettekoven MH, Ratni H, Wettstein JG, Bissantz C. Malherbe P, et al. Among authors: bissantz c. J Med Chem. 2009 Nov 26;52(22):7103-12. doi: 10.1021/jm900948q. J Med Chem. 2009. PMID: 19817444

5

A medicinal chemist's guide to molecular interactions.

Bissantz C, Kuhn B, Stahl M. Bissantz C, et al. J Med Chem. 2010 Jul 22;53(14):5061-84. doi: 10.1021/jm100112j. J Med Chem. 2010. PMID: 20345171 Free PMC article. Review. No abstract available.

6

Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK₁/NK₃ antagonists.

Bissantz C, Bohnert C, Hoffmann T, Marcuz A, Schnider P, Malherbe P. Bissantz C, et al. J Med Chem. 2012 Jun 14;55(11):5061-76. doi: 10.1021/jm2017072. Epub 2012 May 22. J Med Chem. 2012. PMID: 22574973

7

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.

Dehmlow H, Alvarez Sánchez R, Bachmann S, Bissantz C, Bliss F, Conde-Knape K, Graf M, Martin RE, Obst Sander U, Raab S, Richter HG, Sewing S, Sprecher U, Ullmer C, Mattei P. Dehmlow H, et al. Among authors: bissantz c. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4627-32. doi: 10.1016/j.bmcl.2013.06.017. Epub 2013 Jun 19. Bioorg Med Chem Lett. 2013. PMID: 23831134

8

Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.

Malherbe P, Knoflach F, Marcuz A, Bohnert C, Weber M, Knust H, Ratni H, Spooren W, Ballard TM, Bissantz C. Malherbe P, et al. Among authors: bissantz c. Neuropharmacology. 2014 Nov;86:259-72. doi: 10.1016/j.neuropharm.2014.07.017. Epub 2014 Aug 5. Neuropharmacology. 2014. PMID: 25107588

9

Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach.

Ratni H, Rogers-Evans M, Bissantz C, Grundschober C, Moreau JL, Schuler F, Fischer H, Alvarez Sanchez R, Schnider P. Ratni H, et al. Among authors: bissantz c. J Med Chem. 2015 Mar 12;58(5):2275-89. doi: 10.1021/jm501745f. Epub 2015 Feb 18. J Med Chem. 2015. PMID: 25654260

10

A Real-World Perspective on Molecular Design.

Kuhn B, Guba W, Hert J, Banner D, Bissantz C, Ceccarelli S, Haap W, Körner M, Kuglstatter A, Lerner C, Mattei P, Neidhart W, Pinard E, Rudolph MG, Schulz-Gasch T, Woltering T, Stahl M. Kuhn B, et al. Among authors: bissantz c. J Med Chem. 2016 May 12;59(9):4087-102. doi: 10.1021/acs.jmedchem.5b01875. Epub 2016 Feb 24. J Med Chem. 2016. PMID: 26878596

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