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Design and discovery in the development of long-acting renin inhibitors.
Veber DF, Payne LS, Williams PD, Perlow DS, Lundell GF, Gould NP, Siegl PK, Sweet CS, Freidinger RM. Veber DF, et al. Among authors: freidinger rm. Biochem Soc Trans. 1990 Dec;18(6):1291-4. doi: 10.1042/bst0181291. Biochem Soc Trans. 1990. PMID: 2088926 No abstract available.
Renin inhibitors containing 2-substituted statine.
Veber DF, Bock MG, Brady SF, Ulm EH, Cochran DW, Smith GM, LaMont BI, Dipardo RM, Poe M, Freidinger RM, et al. Veber DF, et al. Among authors: freidinger rm. Biochem Soc Trans. 1984 Dec;12(6):956-9. doi: 10.1042/bst0120956. Biochem Soc Trans. 1984. PMID: 6442237 No abstract available.
1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist.
Williams PD, Clineschmidt BV, Erb JM, Freidinger RM, Guidotti MT, Lis EV, Pawluczyk JM, Pettibone DJ, Reiss DR, Veber DF, et al. Williams PD, et al. Among authors: freidinger rm. J Med Chem. 1995 Nov 10;38(23):4634-6. doi: 10.1021/jm00023a002. J Med Chem. 1995. PMID: 7473590 No abstract available.
Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation.
Williams PD, Ball RG, Clineschmidt BV, Culberson JC, Erb JM, Freidinger RM, Pawluczyk JM, Perlow DS, Pettibone DJ, Veber DF. Williams PD, et al. Among authors: freidinger rm. Bioorg Med Chem. 1994 Sep;2(9):971-85. doi: 10.1016/s0968-0896(00)82046-5. Bioorg Med Chem. 1994. PMID: 7712132
84 results