Perlow DS - Search Results

1

Design and discovery in the development of long-acting renin inhibitors.

Veber DF, Payne LS, Williams PD, Perlow DS, Lundell GF, Gould NP, Siegl PK, Sweet CS, Freidinger RM. Veber DF, et al. Among authors: perlow ds. Biochem Soc Trans. 1990 Dec;18(6):1291-4. doi: 10.1042/bst0181291. Biochem Soc Trans. 1990. PMID: 2088926 No abstract available.

2

Design of renin inhibitors containing conformationally restricted mimetics of the P1-P1' and P1 through P2' sites.

Williams PD, Payne LS, Perlow DS, Holloway MK, Siegl PK, Schorn TW, Lynch RJ, Doyle JJ, Strouse JF, Vlasuk GP, et al. Williams PD, et al. Among authors: perlow ds. Adv Exp Med Biol. 1991;306:325-34. doi: 10.1007/978-1-4684-6012-4_38. Adv Exp Med Biol. 1991. PMID: 1812722 No abstract available.

3

Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.

Williams PD, Perlow DS, Payne LS, Holloway MK, Siegl PK, Schorn TW, Lynch RJ, Doyle JJ, Strouse JF, Vlasuk GP, et al. Williams PD, et al. Among authors: perlow ds. J Med Chem. 1991 Mar;34(3):887-900. doi: 10.1021/jm00107a004. J Med Chem. 1991. PMID: 2002469

4

Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product.

Williams PD, Bock MG, Tung RD, Garsky VM, Perlow DS, Erb JM, Lundell GF, Gould NP, Whitter WL, Hoffman JB, et al. Williams PD, et al. Among authors: perlow ds. J Med Chem. 1992 Oct 16;35(21):3905-18. doi: 10.1021/jm00099a019. J Med Chem. 1992. PMID: 1331448

5

Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation.

Williams PD, Ball RG, Clineschmidt BV, Culberson JC, Erb JM, Freidinger RM, Pawluczyk JM, Perlow DS, Pettibone DJ, Veber DF. Williams PD, et al. Among authors: perlow ds. Bioorg Med Chem. 1994 Sep;2(9):971-85. doi: 10.1016/s0968-0896(00)82046-5. Bioorg Med Chem. 1994. PMID: 7712132

6

Nonpeptide oxytocin antagonists: potent, orally bioavailable analogs of L-371,257 containing a 1-R-(pyridyl)ethyl ether terminus.

Kuo MS, Bock MG, Freidinger RM, Guidotti MT, Lis EV, Pawluczyk JM, Perlow DS, Pettibone DJ, Quigley AG, Reiss DR, Williams PD, Woyden CJ. Kuo MS, et al. Among authors: perlow ds. Bioorg Med Chem Lett. 1998 Nov 3;8(21):3081-6. doi: 10.1016/S0960-894X(98)00568-X. Bioorg Med Chem Lett. 1998. PMID: 9873680

7

The selectivity of statine-based inhibitors against various human aspartic proteinases.

Jupp RA, Dunn BM, Jacobs JW, Vlasuk G, Arcuri KE, Veber DF, Perlow DS, Payne LS, Boger J, de Laszlo S, et al. Jupp RA, et al. Among authors: perlow ds. Biochem J. 1990 Feb 1;265(3):871-8. doi: 10.1042/bj2650871. Biochem J. 1990. PMID: 2407237 Free PMC article.

8

Nonpeptide oxytocin antagonists: analogs of L-371,257 with improved potency.

Williams PD, Bock MG, Evans BE, Freidinger RM, Gallicchio SN, Guidotti MT, Jacobson MA, Kuo MS, Levy MR, Lis EV, Michelson SR, Pawluczyk JM, Perlow DS, Pettibone DJ, Quigley AG, Reiss DR, Salvatore C, Stauffer KJ, Woyden CJ. Williams PD, et al. Among authors: perlow ds. Bioorg Med Chem Lett. 1999 May 3;9(9):1311-6. doi: 10.1016/s0960-894x(99)00181-x. Bioorg Med Chem Lett. 1999. PMID: 10340620

9

Synthesis of protected lactam-bridged dipeptides.

Perlow DS, Freidinger RM. Perlow DS, et al. Methods Mol Med. 1999;23:209-25. doi: 10.1385/0-89603-517-4:209. Methods Mol Med. 1999. PMID: 21380900

10

Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog.

Freidinger RM, Veber DF, Perlow DS, Brooks JR, Saperstein R. Freidinger RM, et al. Among authors: perlow ds. Science. 1980 Nov 7;210(4470):656-8. doi: 10.1126/science.7001627. Science. 1980. PMID: 7001627

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