Siegl PK - Search Results

1

Design and discovery in the development of long-acting renin inhibitors.

Veber DF, Payne LS, Williams PD, Perlow DS, Lundell GF, Gould NP, Siegl PK, Sweet CS, Freidinger RM. Veber DF, et al. Among authors: siegl pk. Biochem Soc Trans. 1990 Dec;18(6):1291-4. doi: 10.1042/bst0181291. Biochem Soc Trans. 1990. PMID: 2088926 No abstract available.

2

Design of renin inhibitors containing conformationally restricted mimetics of the P1-P1' and P1 through P2' sites.

Williams PD, Payne LS, Perlow DS, Holloway MK, Siegl PK, Schorn TW, Lynch RJ, Doyle JJ, Strouse JF, Vlasuk GP, et al. Williams PD, et al. Among authors: siegl pk. Adv Exp Med Biol. 1991;306:325-34. doi: 10.1007/978-1-4684-6012-4_38. Adv Exp Med Biol. 1991. PMID: 1812722 No abstract available.

3

Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.

Williams PD, Perlow DS, Payne LS, Holloway MK, Siegl PK, Schorn TW, Lynch RJ, Doyle JJ, Strouse JF, Vlasuk GP, et al. Williams PD, et al. Among authors: siegl pk. J Med Chem. 1991 Mar;34(3):887-900. doi: 10.1021/jm00107a004. J Med Chem. 1991. PMID: 2002469

4

In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.

Siegl PK, Chang RS, Mantlo NB, Chakravarty PK, Ondeyka DL, Greenlee WJ, Patchett AA, Sweet CS, Lotti VJ. Siegl PK, et al. J Pharmacol Exp Ther. 1992 Jul;262(1):139-44. J Pharmacol Exp Ther. 1992. PMID: 1625193

5

Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists.

Mantlo NB, Chakravarty PK, Ondeyka DL, Siegl PK, Chang RS, Lotti VJ, Faust KA, Chen TB, Schorn TW, Sweet CS, et al. Mantlo NB, et al. Among authors: siegl pk. J Med Chem. 1991 Sep;34(9):2919-22. doi: 10.1021/jm00113a035. J Med Chem. 1991. PMID: 1895308 No abstract available.

6

Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.

Selnick HG, Liverton NJ, Baldwin JJ, Butcher JW, Claremon DA, Elliott JM, Freidinger RM, King SA, Libby BE, McIntyre CJ, Pribush DA, Remy DC, Smith GR, Tebben AJ, Jurkiewicz NK, Lynch JJ, Salata JJ, Sanguinetti MC, Siegl PK, Slaughter DE, Vyas K. Selnick HG, et al. Among authors: siegl pk. J Med Chem. 1997 Nov 21;40(24):3865-8. doi: 10.1021/jm970517u. J Med Chem. 1997. PMID: 9397166 No abstract available.

7

Responses to amrinone in isolated cardiac muscles from cat, rabbit, and guinea pig.

Siegl PK, Morgan G, Sweet CS. Siegl PK, et al. J Cardiovasc Pharmacol. 1984 Mar-Apr;6(2):281-7. doi: 10.1097/00005344-198403000-00012. J Cardiovasc Pharmacol. 1984. PMID: 6200717

8

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.

Weber AE, Halgren TA, Doyle JJ, Lynch RJ, Siegl PK, Parsons WH, Greenlee WJ, Patchett AA. Weber AE, et al. Among authors: siegl pk. J Med Chem. 1991 Sep;34(9):2692-701. doi: 10.1021/jm00113a005. J Med Chem. 1991. PMID: 1895289

9

Comparison of cardiovascular responses to the bradycardic drugs, alinidine, AQ-A 39, and mixidine, in the anesthetized dog.

Siegl PK, Wenger HC, Sweet CS. Siegl PK, et al. J Cardiovasc Pharmacol. 1984 Jul-Aug;6(4):565-74. doi: 10.1097/00005344-198407000-00003. J Cardiovasc Pharmacol. 1984. PMID: 6206308

10

Renin inhibitors containing C-termini derived from mercaptoheterocycles.

Ashton WT, Cantone CL, Meurer LC, Tolman RL, Greenlee WJ, Patchett AA, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. Among authors: siegl pk. J Med Chem. 1992 May 29;35(11):2103-12. doi: 10.1021/jm00089a023. J Med Chem. 1992. PMID: 1597860

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