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Novel 1',1'-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist.
Nikas SP, Alapafuja SO, Papanastasiou I, Paronis CA, Shukla VG, Papahatjis DP, Bowman AL, Halikhedkar A, Han X, Makriyannis A. Nikas SP, et al. Among authors: paronis ca. J Med Chem. 2010 Oct 14;53(19):6996-7010. doi: 10.1021/jm100641g. J Med Chem. 2010. PMID: 20925434 Free PMC article.
Diuretic effects of cannabinoids.
Paronis CA, Thakur GA, Bajaj S, Nikas SP, Vemuri VK, Makriyannis A, Bergman J. Paronis CA, et al. J Pharmacol Exp Ther. 2013 Jan;344(1):8-14. doi: 10.1124/jpet.112.199331. Epub 2012 Sep 27. J Pharmacol Exp Ther. 2013. PMID: 23019138 Free PMC article.
Novel adamantyl cannabinoids as CB1 receptor probes.
Thakur GA, Bajaj S, Paronis C, Peng Y, Bowman AL, Barak LS, Caron MG, Parrish D, Deschamps JR, Makriyannis A. Thakur GA, et al. J Med Chem. 2013 May 23;56(10):3904-21. doi: 10.1021/jm4000775. Epub 2013 May 14. J Med Chem. 2013. PMID: 23621789 Free PMC article.
Diuretic effects of cannabinoid agonists in mice.
Chopda GR, Vemuri VK, Sharma R, Thakur GA, Makriyannis A, Paronis CA. Chopda GR, et al. Among authors: paronis ca. Eur J Pharmacol. 2013 Dec 5;721(1-3):64-9. doi: 10.1016/j.ejphar.2013.09.053. Epub 2013 Oct 5. Eur J Pharmacol. 2013. PMID: 24099963 Free PMC article.
Controlled-deactivation cannabinergic ligands.
Sharma R, Nikas SP, Paronis CA, Wood JT, Halikhedkar A, Guo JJ, Thakur GA, Kulkarni S, Benchama O, Raghav JG, Gifford RS, Järbe TU, Bergman J, Makriyannis A. Sharma R, et al. Among authors: paronis ca. J Med Chem. 2013 Dec 27;56(24):10142-57. doi: 10.1021/jm4016075. Epub 2013 Dec 10. J Med Chem. 2013. PMID: 24286207 Free PMC article.
Probing the carboxyester side chain in controlled deactivation (-)-δ(8)-tetrahydrocannabinols.
Nikas SP, Sharma R, Paronis CA, Kulkarni S, Thakur GA, Hurst D, Wood JT, Gifford RS, Rajarshi G, Liu Y, Raghav JG, Guo JJ, Järbe TU, Reggio PH, Bergman J, Makriyannis A. Nikas SP, et al. Among authors: paronis ca. J Med Chem. 2015 Jan 22;58(2):665-81. doi: 10.1021/jm501165d. Epub 2014 Dec 16. J Med Chem. 2015. PMID: 25470070 Free PMC article.
Novel C-Ring-Hydroxy-Substituted Controlled Deactivation Cannabinergic Analogues.
Kulkarni S, Nikas SP, Sharma R, Jiang S, Paronis CA, Leonard MZ, Zhang B, Honrao C, Mallipeddi S, Raghav JG, Benchama O, Järbe TU, Bergman J, Makriyannis A. Kulkarni S, et al. Among authors: paronis ca. J Med Chem. 2016 Jul 28;59(14):6903-19. doi: 10.1021/acs.jmedchem.6b00717. Epub 2016 Jul 13. J Med Chem. 2016. PMID: 27367336 Free PMC article.
Long-Lasting In Vivo Effects of the Cannabinoid CB1 Antagonist AM6538.
Paronis CA, Chopda GR, Vemuri K, Zakarian AS, Makriyannis A, Bergman J. Paronis CA, et al. J Pharmacol Exp Ther. 2018 Mar;364(3):485-493. doi: 10.1124/jpet.117.245647. Epub 2018 Jan 8. J Pharmacol Exp Ther. 2018. PMID: 29311110 Free PMC article.
53 results