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The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
Loveridge C, Tonelli F, Leclercq T, Lim KG, Long JS, Berdyshev E, Tate RJ, Natarajan V, Pitson SM, Pyne NJ, Pyne S. Loveridge C, et al. Among authors: natarajan v. J Biol Chem. 2010 Dec 10;285(50):38841-52. doi: 10.1074/jbc.M110.127993. Epub 2010 Oct 6. J Biol Chem. 2010. PMID: 20926375 Free PMC article.
Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases.
Zhao Y, He D, Saatian B, Watkins T, Spannhake EW, Pyne NJ, Natarajan V. Zhao Y, et al. Among authors: natarajan v. J Biol Chem. 2006 Jul 14;281(28):19501-11. doi: 10.1074/jbc.M511224200. Epub 2006 May 10. J Biol Chem. 2006. PMID: 16687414 Free PMC article.
Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1.
Zhao Y, Kalari SK, Usatyuk PV, Gorshkova I, He D, Watkins T, Brindley DN, Sun C, Bittman R, Garcia JG, Berdyshev EV, Natarajan V. Zhao Y, et al. Among authors: natarajan v. J Biol Chem. 2007 May 11;282(19):14165-77. doi: 10.1074/jbc.M701279200. Epub 2007 Mar 22. J Biol Chem. 2007. PMID: 17379599 Free PMC article.
Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1.
Gorshkova I, He D, Berdyshev E, Usatuyk P, Burns M, Kalari S, Zhao Y, Pendyala S, Garcia JG, Pyne NJ, Brindley DN, Natarajan V. Gorshkova I, et al. Among authors: natarajan v. J Biol Chem. 2008 Apr 25;283(17):11794-806. doi: 10.1074/jbc.M800250200. Epub 2008 Feb 22. J Biol Chem. 2008. PMID: 18296444 Free PMC article.
663 results