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The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
Loveridge C, Tonelli F, Leclercq T, Lim KG, Long JS, Berdyshev E, Tate RJ, Natarajan V, Pitson SM, Pyne NJ, Pyne S. Loveridge C, et al. Among authors: pitson sm. J Biol Chem. 2010 Dec 10;285(50):38841-52. doi: 10.1074/jbc.M110.127993. Epub 2010 Oct 6. J Biol Chem. 2010. PMID: 20926375 Free PMC article.
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ. Tonelli F, et al. Among authors: pitson sm. Cell Signal. 2010 Oct;22(10):1536-42. doi: 10.1016/j.cellsig.2010.05.022. Epub 2010 Jun 4. Cell Signal. 2010. PMID: 20570726 Free PMC article.
Sphingosine kinase localization in the control of sphingolipid metabolism.
Siow DL, Anderson CD, Berdyshev EV, Skobeleva A, Natarajan V, Pitson SM, Wattenberg BW. Siow DL, et al. Among authors: pitson sm. Adv Enzyme Regul. 2011;51(1):229-44. doi: 10.1016/j.advenzreg.2010.09.004. Epub 2010 Nov 12. Adv Enzyme Regul. 2011. PMID: 21075134 Free PMC article.
An oncogenic role for sphingosine kinase 2.
Neubauer HA, Pham DH, Zebol JR, Moretti PA, Peterson AL, Leclercq TM, Chan H, Powell JA, Pitman MR, Samuel MS, Bonder CS, Creek DJ, Gliddon BL, Pitson SM. Neubauer HA, et al. Among authors: pitson sm. Oncotarget. 2016 Oct 4;7(40):64886-64899. doi: 10.18632/oncotarget.11714. Oncotarget. 2016. PMID: 27588496 Free PMC article.
167 results