Wittinghofer A - Search Results

1

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.

Gremer L, Merbitz-Zahradnik T, Dvorsky R, Cirstea IC, Kratz CP, Zenker M, Wittinghofer A, Ahmadian MR. Gremer L, et al. Among authors: wittinghofer a. Hum Mutat. 2011 Jan;32(1):33-43. doi: 10.1002/humu.21377. Epub 2010 Dec 9. Hum Mutat. 2011. PMID: 20949621 Free PMC article.

2

A restricted spectrum of NRAS mutations causes Noonan syndrome.

Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, König R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M. Cirstea IC, et al. Among authors: wittinghofer a. Nat Genet. 2010 Jan;42(1):27-9. doi: 10.1038/ng.497. Epub 2009 Dec 6. Nat Genet. 2010. PMID: 19966803 Free PMC article.

3

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction.

Gremer L, Gilsbach B, Ahmadian MR, Wittinghofer A. Gremer L, et al. Among authors: wittinghofer a. Biol Chem. 2008 Sep;389(9):1163-71. doi: 10.1515/BC.2008.132. Biol Chem. 2008. PMID: 18713003

4

The interaction of Ras with GTPase-activating proteins.

Wittinghofer A, Scheffzek K, Ahmadian MR. Wittinghofer A, et al. FEBS Lett. 1997 Jun 23;410(1):63-7. doi: 10.1016/s0014-5793(97)00321-9. FEBS Lett. 1997. PMID: 9247124 Free article. Review.

5

GTPase-activating proteins: helping hands to complement an active site.

Scheffzek K, Ahmadian MR, Wittinghofer A. Scheffzek K, et al. Among authors: wittinghofer a. Trends Biochem Sci. 1998 Jul;23(7):257-62. doi: 10.1016/s0968-0004(98)01224-9. Trends Biochem Sci. 1998. PMID: 9697416 Review.

6

Oncogenic insertional mutations in the P-loop of Ras are overactive in MAP kinase signaling.

Klockow B, Ahmadian MR, Block C, Wittinghofer A. Klockow B, et al. Among authors: wittinghofer a. Oncogene. 2000 Nov 9;19(47):5367-76. doi: 10.1038/sj.onc.1203909. Oncogene. 2000. PMID: 11103938

7

Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time.

Allin C, Ahmadian MR, Wittinghofer A, Gerwert K. Allin C, et al. Among authors: wittinghofer a. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7754-9. doi: 10.1073/pnas.131549798. Proc Natl Acad Sci U S A. 2001. PMID: 11438727 Free PMC article.

8

The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins.

Gasper R, Thomas C, Ahmadian MR, Wittinghofer A. Gasper R, et al. Among authors: wittinghofer a. J Mol Biol. 2008 May 23;379(1):51-63. doi: 10.1016/j.jmb.2008.03.011. Epub 2008 Mar 14. J Mol Biol. 2008. PMID: 18440551

9

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.

Blaževitš O, Mideksa YG, Šolman M, Ligabue A, Ariotti N, Nakhaeizadeh H, Fansa EK, Papageorgiou AC, Wittinghofer A, Ahmadian MR, Abankwa D. Blaževitš O, et al. Among authors: wittinghofer a. Sci Rep. 2016 Apr 18;6:24165. doi: 10.1038/srep24165. Sci Rep. 2016. PMID: 27087647 Free PMC article.

10

Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy.

Ahmadian MR, Hoffmann U, Goody RS, Wittinghofer A. Ahmadian MR, et al. Among authors: wittinghofer a. Biochemistry. 1997 Apr 15;36(15):4535-41. doi: 10.1021/bi962556y. Biochemistry. 1997. PMID: 9109662

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