Hewitt D - Search Results

1

Mixed-mode and reversed-phase liquid chromatography-tandem mass spectrometry methodologies to study composition and base hydrolysis of polysorbate 20 and 80.

Hewitt D, Alvarez M, Robinson K, Ji J, Wang YJ, Kao YH, Zhang T. Hewitt D, et al. J Chromatogr A. 2011 Apr 15;1218(15):2138-45. doi: 10.1016/j.chroma.2010.09.057. Epub 2010 Sep 29. J Chromatogr A. 2011. PMID: 20950816

2

Quantitation of polysorbate 20 in protein solutions using mixed-mode chromatography and evaporative light scattering detection.

Hewitt D, Zhang T, Kao YH. Hewitt D, et al. J Chromatogr A. 2008 Dec 26;1215(1-2):156-60. doi: 10.1016/j.chroma.2008.11.017. Epub 2008 Nov 14. J Chromatogr A. 2008. PMID: 19036378

3

The effects of membrane filters used in biopharmaceutical processes on the concentration and composition of polysorbate 20.

Lei M, Sugahara J, Hewitt D, Beane D, Jayakar R, Cornell C, Skidmore K, Kao YH, Ji J. Lei M, et al. Among authors: hewitt d. Biotechnol Prog. 2013 Nov-Dec;29(6):1503-11. doi: 10.1002/btpr.1824. Epub 2013 Oct 23. Biotechnol Prog. 2013. PMID: 24124005

4

Characterization and stability study of polysorbate 20 in therapeutic monoclonal antibody formulation by multidimensional ultrahigh-performance liquid chromatography-charged aerosol detection-mass spectrometry.

Li Y, Hewitt D, Lentz YK, Ji JA, Zhang TY, Zhang K. Li Y, et al. Among authors: hewitt d. Anal Chem. 2014 May 20;86(10):5150-7. doi: 10.1021/ac5009628. Epub 2014 May 2. Anal Chem. 2014. PMID: 24749737

5

Rapid identification of low level glycation sites in recombinant antibodies by isotopic labeling with 13C6-reducing sugars.

Zhang J, Zhang T, Jiang L, Hewitt D, Huang Y, Kao YH, Katta V. Zhang J, et al. Among authors: hewitt d. Anal Chem. 2012 Mar 6;84(5):2313-20. doi: 10.1021/ac202995x. Epub 2012 Feb 24. Anal Chem. 2012. PMID: 22324758

6

Identification and characterization of buried unpaired cysteines in a recombinant monoclonal IgG1 antibody.

Zhang T, Zhang J, Hewitt D, Tran B, Gao X, Qiu ZJ, Tejada M, Gazzano-Santoro H, Kao YH. Zhang T, et al. Among authors: hewitt d. Anal Chem. 2012 Aug 21;84(16):7112-23. doi: 10.1021/ac301426h. Epub 2012 Aug 1. Anal Chem. 2012. PMID: 22794164

7

Identification of a single base-pair mutation of TAA (Stop codon) → GAA (Glu) that causes light chain extension in a CHO cell derived IgG1.

Zhang T, Huang Y, Chamberlain S, Romeo T, Zhu-Shimoni J, Hewitt D, Zhu M, Katta V, Mauger B, Kao YH. Zhang T, et al. Among authors: hewitt d. MAbs. 2012 Nov-Dec;4(6):694-700. doi: 10.4161/mabs.22232. Epub 2012 Sep 27. MAbs. 2012. PMID: 23018810 Free PMC article.

8

Mechanism of antibody reduction in cell culture production processes.

Kao YH, Hewitt DP, Trexler-Schmidt M, Laird MW. Kao YH, et al. Biotechnol Bioeng. 2010 Nov 1;107(4):622-32. doi: 10.1002/bit.22848. Biotechnol Bioeng. 2010. PMID: 20589844

9

Quantitation and characterization of process impurities and extractables in protein-containing solutions using proton NMR as a general tool.

Skidmore K, Hewitt D, Kao YH. Skidmore K, et al. Among authors: hewitt d. Biotechnol Prog. 2012 Nov-Dec;28(6):1526-33. doi: 10.1002/btpr.1620. Epub 2012 Nov 1. Biotechnol Prog. 2012. PMID: 22915490

10

Facile quantitation of free thiols in a recombinant monoclonal antibody by reversed-phase high performance liquid chromatography with hydrophobicity-tailored thiol derivatization.

Welch L, Dong X, Hewitt D, Irwin M, McCarty L, Tsai C, Baginski T. Welch L, et al. Among authors: hewitt d. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:158-167. doi: 10.1016/j.jchromb.2018.05.039. Epub 2018 Jun 2. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29906677

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