Kao YH - Search Results

1

Mixed-mode and reversed-phase liquid chromatography-tandem mass spectrometry methodologies to study composition and base hydrolysis of polysorbate 20 and 80.

Hewitt D, Alvarez M, Robinson K, Ji J, Wang YJ, Kao YH, Zhang T. Hewitt D, et al. Among authors: kao yh. J Chromatogr A. 2011 Apr 15;1218(15):2138-45. doi: 10.1016/j.chroma.2010.09.057. Epub 2010 Sep 29. J Chromatogr A. 2011. PMID: 20950816

2

Quantitation of polysorbate 20 in protein solutions using mixed-mode chromatography and evaporative light scattering detection.

Hewitt D, Zhang T, Kao YH. Hewitt D, et al. Among authors: kao yh. J Chromatogr A. 2008 Dec 26;1215(1-2):156-60. doi: 10.1016/j.chroma.2008.11.017. Epub 2008 Nov 14. J Chromatogr A. 2008. PMID: 19036378

3

On-line characterization of monoclonal antibody variants by liquid chromatography-mass spectrometry operating in a two-dimensional format.

Alvarez M, Tremintin G, Wang J, Eng M, Kao YH, Jeong J, Ling VT, Borisov OV. Alvarez M, et al. Among authors: kao yh. Anal Biochem. 2011 Dec 1;419(1):17-25. doi: 10.1016/j.ab.2011.07.033. Epub 2011 Aug 2. Anal Biochem. 2011. PMID: 21867674

4

Rapid identification of low level glycation sites in recombinant antibodies by isotopic labeling with 13C6-reducing sugars.

Zhang J, Zhang T, Jiang L, Hewitt D, Huang Y, Kao YH, Katta V. Zhang J, et al. Among authors: kao yh. Anal Chem. 2012 Mar 6;84(5):2313-20. doi: 10.1021/ac202995x. Epub 2012 Feb 24. Anal Chem. 2012. PMID: 22324758

5

Identification and characterization of buried unpaired cysteines in a recombinant monoclonal IgG1 antibody.

Zhang T, Zhang J, Hewitt D, Tran B, Gao X, Qiu ZJ, Tejada M, Gazzano-Santoro H, Kao YH. Zhang T, et al. Among authors: kao yh. Anal Chem. 2012 Aug 21;84(16):7112-23. doi: 10.1021/ac301426h. Epub 2012 Aug 1. Anal Chem. 2012. PMID: 22794164

6

The effects of membrane filters used in biopharmaceutical processes on the concentration and composition of polysorbate 20.

Lei M, Sugahara J, Hewitt D, Beane D, Jayakar R, Cornell C, Skidmore K, Kao YH, Ji J. Lei M, et al. Among authors: kao yh. Biotechnol Prog. 2013 Nov-Dec;29(6):1503-11. doi: 10.1002/btpr.1824. Epub 2013 Oct 23. Biotechnol Prog. 2013. PMID: 24124005

7

Identification of a single base-pair mutation of TAA (Stop codon) → GAA (Glu) that causes light chain extension in a CHO cell derived IgG1.

Zhang T, Huang Y, Chamberlain S, Romeo T, Zhu-Shimoni J, Hewitt D, Zhu M, Katta V, Mauger B, Kao YH. Zhang T, et al. Among authors: kao yh. MAbs. 2012 Nov-Dec;4(6):694-700. doi: 10.4161/mabs.22232. Epub 2012 Sep 27. MAbs. 2012. PMID: 23018810 Free PMC article.

8

Characterization of asparagine 330 deamidation in an Fc-fragment of IgG1 using cation exchange chromatography and peptide mapping.

Zhang YT, Hu J, Pace AL, Wong R, Wang YJ, Kao YH. Zhang YT, et al. Among authors: kao yh. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15;965:65-71. doi: 10.1016/j.jchromb.2014.06.018. Epub 2014 Jun 21. J Chromatogr B Analyt Technol Biomed Life Sci. 2014. PMID: 24999246

9

Mechanism of antibody reduction in cell culture production processes.

Kao YH, Hewitt DP, Trexler-Schmidt M, Laird MW. Kao YH, et al. Biotechnol Bioeng. 2010 Nov 1;107(4):622-32. doi: 10.1002/bit.22848. Biotechnol Bioeng. 2010. PMID: 20589844

10

Quantitation and characterization of process impurities and extractables in protein-containing solutions using proton NMR as a general tool.

Skidmore K, Hewitt D, Kao YH. Skidmore K, et al. Among authors: kao yh. Biotechnol Prog. 2012 Nov-Dec;28(6):1526-33. doi: 10.1002/btpr.1620. Epub 2012 Nov 1. Biotechnol Prog. 2012. PMID: 22915490

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