Fielder PJ - Search Results

1

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

Deng R, Iyer S, Theil FP, Mortensen DL, Fielder PJ, Prabhu S. Deng R, et al. Among authors: fielder pj. MAbs. 2011 Jan-Feb;3(1):61-6. doi: 10.4161/mabs.3.1.13799. Epub 2011 Jan 1. MAbs. 2011. PMID: 20962582 Free PMC article.

2

A strategy for risk mitigation of antibodies with fast clearance.

Hötzel I, Theil FP, Bernstein LJ, Prabhu S, Deng R, Quintana L, Lutman J, Sibia R, Chan P, Bumbaca D, Fielder P, Carter PJ, Kelley RF. Hötzel I, et al. Among authors: fielder p. MAbs. 2012 Nov-Dec;4(6):753-60. doi: 10.4161/mabs.22189. MAbs. 2012. PMID: 23778268 Free PMC article.

3

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys.

Deng R, Loyet KM, Lien S, Iyer S, DeForge LE, Theil FP, Lowman HB, Fielder PJ, Prabhu S. Deng R, et al. Among authors: fielder pj. Drug Metab Dispos. 2010 Apr;38(4):600-5. doi: 10.1124/dmd.109.031310. Epub 2010 Jan 13. Drug Metab Dispos. 2010. PMID: 20071453 Clinical Trial.

4

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice.

Deng R, Meng YG, Hoyte K, Lutman J, Lu Y, Iyer S, DeForge LE, Theil FP, Fielder PJ, Prabhu S. Deng R, et al. Among authors: fielder pj. MAbs. 2012 Jan-Feb;4(1):101-9. doi: 10.4161/mabs.4.1.18543. MAbs. 2012. PMID: 22327433 Free PMC article.

5

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, Li J, McVay S, O'Mahony J, Otteneder M, Pantze M, Putnam WS, Qiu ZJ, Ruppel J, Singer T, Stauch O, Theil FP, Visich J, Yang J, Ying Y, Khawli LA, Richter WF. Zheng Y, et al. Among authors: fielder pj. MAbs. 2012 Mar-Apr;4(2):243-55. doi: 10.4161/mabs.4.2.19387. Epub 2012 Mar 1. MAbs. 2012. PMID: 22453096 Free PMC article.

6

Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies.

Mortensen DL, Prabhu S, Stefanich EG, Kadkhodayan-Fischer S, Gelzleichter TR, Baker D, Jiang J, Wallace K, Iyer S, Fielder PJ, Putnam WS. Mortensen DL, et al. Among authors: fielder pj. MAbs. 2012 Nov-Dec;4(6):724-31. doi: 10.4161/mabs.22216. MAbs. 2012. PMID: 23778267 Free PMC article.

7

Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development.

Wang J, Iyer S, Fielder PJ, Davis JD, Deng R. Wang J, et al. Among authors: fielder pj. Biopharm Drug Dispos. 2016 Mar;37(2):51-65. doi: 10.1002/bdd.1952. Epub 2015 May 15. Biopharm Drug Dispos. 2016. PMID: 25869767 Review.

8

Development and evaluation of a novel method for preclinical measurement of tissue vascular volume.

Boswell CA, Ferl GZ, Mundo EE, Schweiger MG, Marik J, Reich MP, Theil FP, Fielder PJ, Khawli LA. Boswell CA, et al. Among authors: fielder pj. Mol Pharm. 2010 Oct 4;7(5):1848-57. doi: 10.1021/mp100183k. Epub 2010 Aug 12. Mol Pharm. 2010. PMID: 20704296

9

Effects of charge on antibody tissue distribution and pharmacokinetics.

Boswell CA, Tesar DB, Mukhyala K, Theil FP, Fielder PJ, Khawli LA. Boswell CA, et al. Among authors: fielder pj. Bioconjug Chem. 2010 Dec 15;21(12):2153-63. doi: 10.1021/bc100261d. Epub 2010 Nov 5. Bioconjug Chem. 2010. PMID: 21053952 Review.

10

Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.

Boswell CA, Mundo EE, Zhang C, Bumbaca D, Valle NR, Kozak KR, Fourie A, Chuh J, Koppada N, Saad O, Gill H, Shen BQ, Rubinfeld B, Tibbitts J, Kaur S, Theil FP, Fielder PJ, Khawli LA, Lin K. Boswell CA, et al. Among authors: fielder pj. Bioconjug Chem. 2011 Oct 19;22(10):1994-2004. doi: 10.1021/bc200212a. Epub 2011 Oct 3. Bioconjug Chem. 2011. PMID: 21913715

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