Kienhuis AS - Search Results

1

Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study.

Kienhuis AS, Bessems JG, Pennings JL, Driessen M, Luijten M, van Delft JH, Peijnenburg AA, van der Ven LT. Kienhuis AS, et al. Toxicol Appl Pharmacol. 2011 Jan 15;250(2):96-107. doi: 10.1016/j.taap.2010.10.013. Epub 2010 Oct 21. Toxicol Appl Pharmacol. 2011. PMID: 20970440 Review.

2

Vegetables affect the expression of genes involved in anticarcinogenic processes in the colonic mucosa of C57BL/6 female mice.

van Breda SG, van Agen E, van Sanden S, Burzykowski T, Kienhuis AS, Kleinjans JC, van Delft JH. van Breda SG, et al. Among authors: kienhuis as. J Nutr. 2005 Aug;135(8):1879-88. doi: 10.1093/jn/135.8.1879. J Nutr. 2005. PMID: 16046712 Free article.

3

Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals.

Stierum R, Heijne W, Kienhuis A, van Ommen B, Groten J. Stierum R, et al. Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):179-88. doi: 10.1016/j.taap.2005.01.050. Toxicol Appl Pharmacol. 2005. PMID: 16139318 Review.

4

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology.

Heijne WH, Kienhuis AS, van Ommen B, Stierum RH, Groten JP. Heijne WH, et al. Among authors: kienhuis as. Expert Rev Proteomics. 2005 Oct;2(5):767-80. doi: 10.1586/14789450.2.5.767. Expert Rev Proteomics. 2005. PMID: 16209655 Review.

5

Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: a toxicogenomics approach.

Kienhuis AS, Wortelboer HM, Hoflack JC, Moonen EJ, Kleinjans JC, van Ommen B, van Delft JH, Stierum RH. Kienhuis AS, et al. Drug Metab Dispos. 2006 Dec;34(12):2083-90. doi: 10.1124/dmd.106.011262. Epub 2006 Sep 8. Drug Metab Dispos. 2006. PMID: 16963487

6

A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling.

Kienhuis AS, Wortelboer HM, Maas WJ, van Herwijnen M, Kleinjans JC, van Delft JH, Stierum RH. Kienhuis AS, et al. Toxicol In Vitro. 2007 Aug;21(5):892-901. doi: 10.1016/j.tiv.2007.01.010. Epub 2007 Jan 20. Toxicol In Vitro. 2007. PMID: 17336492

7

Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.

Kienhuis AS, van de Poll MC, Wortelboer H, van Herwijnen M, Gottschalk R, Dejong CH, Boorsma A, Paules RS, Kleinjans JC, Stierum RH, van Delft JH. Kienhuis AS, et al. Toxicol Sci. 2009 Feb;107(2):544-52. doi: 10.1093/toxsci/kfn237. Epub 2008 Nov 12. Toxicol Sci. 2009. PMID: 19008212

8

Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes.

Mathijs K, Kienhuis AS, Brauers KJ, Jennen DG, Lahoz A, Kleinjans JC, van Delft JH. Mathijs K, et al. Among authors: kienhuis as. Drug Metab Dispos. 2009 Jun;37(6):1305-11. doi: 10.1124/dmd.108.025775. Epub 2009 Feb 27. Drug Metab Dispos. 2009. PMID: 19251822

9

A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.

Kienhuis AS, van de Poll MC, Dejong CH, Gottschalk R, van Herwijnen M, Boorsma A, Kleinjans JC, Stierum RH, van Delft JH. Kienhuis AS, et al. Toxicol In Vitro. 2009 Sep;23(6):1163-9. doi: 10.1016/j.tiv.2009.06.005. Epub 2009 Jun 13. Toxicol In Vitro. 2009. PMID: 19527782

10

Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling.

Driessen M, Kienhuis AS, Pennings JL, Pronk TE, van de Brandhof EJ, Roodbergen M, Spaink HP, van de Water B, van der Ven LT. Driessen M, et al. Among authors: kienhuis as. Arch Toxicol. 2013 May;87(5):807-23. doi: 10.1007/s00204-013-1039-z. Epub 2013 Apr 6. Arch Toxicol. 2013. PMID: 23559145

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