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Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.
Kienhuis AS, van de Poll MC, Wortelboer H, van Herwijnen M, Gottschalk R, Dejong CH, Boorsma A, Paules RS, Kleinjans JC, Stierum RH, van Delft JH. Kienhuis AS, et al. Among authors: van herwijnen m, van de poll mc, van delft jh. Toxicol Sci. 2009 Feb;107(2):544-52. doi: 10.1093/toxsci/kfn237. Epub 2008 Nov 12. Toxicol Sci. 2009. PMID: 19008212
A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.
Kienhuis AS, van de Poll MC, Dejong CH, Gottschalk R, van Herwijnen M, Boorsma A, Kleinjans JC, Stierum RH, van Delft JH. Kienhuis AS, et al. Among authors: van herwijnen m, van de poll mc, van delft jh. Toxicol In Vitro. 2009 Sep;23(6):1163-9. doi: 10.1016/j.tiv.2009.06.005. Epub 2009 Jun 13. Toxicol In Vitro. 2009. PMID: 19527782
'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.
Jetten MJ, Gaj S, Ruiz-Aracama A, de Kok TM, van Delft JH, Lommen A, van Someren EP, Jennen DG, Claessen SM, Peijnenburg AA, Stierum RH, Kleinjans JC. Jetten MJ, et al. Among authors: van someren ep, van delft jh. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):320-8. doi: 10.1016/j.taap.2012.01.009. Epub 2012 Jan 20. Toxicol Appl Pharmacol. 2012. PMID: 22285215 Clinical Trial.
Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis.
Kienhuis AS, Vitins AP, Pennings JL, Pronk TE, Speksnijder EN, Roodbergen M, van Delft JH, Luijten M, van der Ven LT. Kienhuis AS, et al. Among authors: van der ven lt, van delft jh. Toxicol Lett. 2013 Aug 29;221(3):225-36. doi: 10.1016/j.toxlet.2013.06.236. Epub 2013 Jul 3. Toxicol Lett. 2013. PMID: 23830897
142 results