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Page 1
Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2.
Haffner CD, Thomson SA, Guo Y, Petrov K, Larkin A, Banker P, Schaaf G, Dickerson S, Gobel J, Gillie D, Condreay JP, Poole C, Carpenter T, Ulrich J. Haffner CD, et al. Among authors: thomson sa. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6989-92. doi: 10.1016/j.bmcl.2010.09.131. Epub 2010 Oct 23. Bioorg Med Chem Lett. 2010. PMID: 20974533
Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.
Thomson SA, Banker P, Bickett DM, Boucheron JA, Carter HL, Clancy DC, Cooper JP, Dickerson SH, Garrido DM, Nolte RT, Peat AJ, Sheckler LR, Sparks SM, Tavares FX, Wang L, Wang TY, Weiel JE. Thomson SA, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1177-82. doi: 10.1016/j.bmcl.2008.12.085. Epub 2008 Dec 25. Bioorg Med Chem Lett. 2009. PMID: 19138846
Novel GSK-3 inhibitors with improved cellular activity.
Peat AJ, Garrido D, Boucheron JA, Schweiker SL, Dickerson SH, Wilson JR, Wang TY, Thomson SA. Peat AJ, et al. Among authors: thomson sa. Bioorg Med Chem Lett. 2004 May 3;14(9):2127-30. doi: 10.1016/j.bmcl.2004.02.037. Bioorg Med Chem Lett. 2004. PMID: 15080993
Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups.
Sparks SM, Banker P, Bickett DM, Carter HL, Clancy DC, Dickerson SH, Dwornik KA, Garrido DM, Golden PL, Nolte RT, Peat AJ, Sheckler LR, Tavares FX, Thomson SA, Wang L, Weiel JE. Sparks SM, et al. Among authors: thomson sa. Bioorg Med Chem Lett. 2009 Feb 1;19(3):976-80. doi: 10.1016/j.bmcl.2008.11.085. Epub 2008 Nov 27. Bioorg Med Chem Lett. 2009. PMID: 19095442
Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of Type 2 diabetes: 2. Optimization of serine and threonine ether amino acid residues.
Sparks SM, Banker P, Bickett DM, Clancy DC, Dickerson SH, Garrido DM, Golden PL, Peat AJ, Sheckler LR, Tavares FX, Thomson SA, Weiel JE. Sparks SM, et al. Among authors: thomson sa. Bioorg Med Chem Lett. 2009 Feb 1;19(3):981-5. doi: 10.1016/j.bmcl.2008.11.084. Epub 2008 Nov 27. Bioorg Med Chem Lett. 2009. PMID: 19095443
Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors.
Peat AJ, Boucheron JA, Dickerson SH, Garrido D, Mills W, Peckham J, Preugschat F, Smalley T, Schweiker SL, Wilson JR, Wang TY, Zhou HQ, Thomson SA. Peat AJ, et al. Among authors: thomson sa. Bioorg Med Chem Lett. 2004 May 3;14(9):2121-5. doi: 10.1016/j.bmcl.2004.02.036. Bioorg Med Chem Lett. 2004. PMID: 15080992
Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3.
Smalley TL Jr, Peat AJ, Boucheron JA, Dickerson S, Garrido D, Preugschat F, Schweiker SL, Thomson SA, Wang TY. Smalley TL Jr, et al. Among authors: thomson sa. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2091-4. doi: 10.1016/j.bmcl.2006.01.057. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16460937
The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
Deaton DN, Do Y, Holt J, Jeune MR, Kramer HF, Larkin AL, Orband-Miller LA, Peckham GE, Poole C, Price DJ, Schaller LT, Shen Y, Shewchuk LM, Stewart EL, Stuart JD, Thomson SA, Ward P, Wilson JW, Xu T, Guss JH, Musetti C, Rendina AR, Affleck K, Anders D, Hancock AP, Hobbs H, Hodgson ST, Hutchinson J, Leveridge MV, Nicholls H, Smith IED, Somers DO, Sneddon HF, Uddin S, Cleasby A, Mortenson PN, Richardson C, Saxty G. Deaton DN, et al. Among authors: thomson sa. Bioorg Med Chem. 2019 Apr 15;27(8):1456-1478. doi: 10.1016/j.bmc.2019.02.017. Epub 2019 Feb 11. Bioorg Med Chem. 2019. PMID: 30858025
96 results