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Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, Ward SA, O'Neill PM. Gibbons P, et al. Among authors: araujo nc. J Med Chem. 2010 Nov 25;53(22):8202-6. doi: 10.1021/jm1009567. Epub 2010 Oct 27. J Med Chem. 2010. PMID: 20979352
Design and synthesis of endoperoxide antimalarial prodrug models.
O'Neill PM, Stocks PA, Pugh MD, Araujo NC, Korshin EE, Bickley JF, Ward SA, Bray PG, Pasini E, Davies J, Verissimo E, Bachi MD. O'Neill PM, et al. Among authors: araujo nc. Angew Chem Int Ed Engl. 2004 Aug 13;43(32):4193-7. doi: 10.1002/anie.200453859. Angew Chem Int Ed Engl. 2004. PMID: 15307085 No abstract available.
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Stocks PA, Bray PG, Barton VE, Al-Helal M, Jones M, Araujo NC, Gibbons P, Ward SA, Hughes RH, Biagini GA, Davies J, Amewu R, Mercer AE, Ellis G, O'Neill PM. Stocks PA, et al. Among authors: araujo nc. Angew Chem Int Ed Engl. 2007;46(33):6278-83. doi: 10.1002/anie.200604697. Angew Chem Int Ed Engl. 2007. PMID: 17640025 No abstract available.
Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.
La Pensée L, Sabbani S, Sharma R, Bhamra I, Shore E, Chadwick AE, Berry NG, Firman J, Araujo NC, Cabral L, Cristiano ML, Bateman C, Janneh O, Gavrila A, Wu YH, Hussain A, Ward SA, Stocks PA, Cosstick R, O'Neill PM. La Pensée L, et al. Among authors: araujo nc. ChemMedChem. 2013 May;8(5):709-18. doi: 10.1002/cmdc.201200536. Epub 2013 Mar 11. ChemMedChem. 2013. PMID: 23495190
64 results