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Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis.
Singh S, Roy KK, Khan SR, Kashyap VK, Sharma A, Jaiswal S, Sharma SK, Krishnan MY, Chaturvedi V, Lal J, Sinha S, Dasgupta A, Srivastava R, Saxena AK. Singh S, et al. Among authors: dasgupta a. Bioorg Med Chem. 2015 Feb 15;23(4):742-52. doi: 10.1016/j.bmc.2014.12.060. Epub 2015 Jan 2. Bioorg Med Chem. 2015. PMID: 25614114
Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.
Shyam M, Verma H, Bhattacharje G, Mukherjee P, Singh S, Kamilya S, Jalani P, Das S, Dasgupta A, Mondal A, Das AK, Singh A, Brucoli F, Bagnéris C, Dickman R, Basavanakatti VN, Naresh Babu P, Sankaran V, Dev A, Sinha BN, Bhakta S, Jayaprakash V. Shyam M, et al. Among authors: dasgupta a. J Med Chem. 2022 Jan 13;65(1):234-256. doi: 10.1021/acs.jmedchem.1c01349. Epub 2022 Jan 4. J Med Chem. 2022. PMID: 34981940
Identification of nitrofuranylchalcone tethered benzoxazole-2-amines as potent inhibitors of drug resistant Mycobacterium tuberculosis demonstrating bactericidal efficacy.
Kumar Sahoo S, Maddipatla S, Nageswara Rao Gajula S, Naiyaz Ahmad M, Kaul G, Nanduri S, Sonti R, Dasgupta A, Chopra S, Madhavi Yaddanapudi V. Kumar Sahoo S, et al. Among authors: dasgupta a. Bioorg Med Chem. 2022 Jun 15;64:116777. doi: 10.1016/j.bmc.2022.116777. Epub 2022 Apr 23. Bioorg Med Chem. 2022. PMID: 35487101
Synthesis and structure-activity relationship of new chalcone linked 5-phenyl-3-isoxazolecarboxylic acid methyl esters potentially active against drug resistant Mycobacterium tuberculosis.
Sahoo SK, Rani B, Gaikwad NB, Ahmad MN, Kaul G, Shukla M, Nanduri S, Dasgupta A, Chopra S, Yaddanapudi VM. Sahoo SK, et al. Among authors: dasgupta a. Eur J Med Chem. 2021 Oct 15;222:113580. doi: 10.1016/j.ejmech.2021.113580. Epub 2021 Jun 2. Eur J Med Chem. 2021. PMID: 34116324
1,703 results