Flores CM - Search Results

1

An integrated multiassay approach to the discovery of small-molecule N-type voltage-gated calcium channel antagonists.

Finley MF, Lubin ML, Neeper MP, Beck E, Liu Y, Flores CM, Qin N. Finley MF, et al. Among authors: flores cm. Assay Drug Dev Technol. 2010 Dec;8(6):685-94. doi: 10.1089/adt.2010.0311. Epub 2010 Nov 4. Assay Drug Dev Technol. 2010. PMID: 21050074

2

Development and validation of a secondary screening assay for TRPM8 antagonists using QPatch HT.

Beck EJ, Hutchinson TL, Qin N, Flores CM, Liu Y. Beck EJ, et al. Among authors: flores cm. Assay Drug Dev Technol. 2010 Feb;8(1):63-72. doi: 10.1089/adt.2009.0214. Assay Drug Dev Technol. 2010. PMID: 20085457

3

Validation of a patch clamp screening protocol that simultaneously measures compound activity in multiple states of the voltage-gated sodium channel Nav1.2.

Liu Y, Beck EJ, Flores CM. Liu Y, et al. Among authors: flores cm. Assay Drug Dev Technol. 2011 Dec;9(6):628-34. doi: 10.1089/adt.2011.0375. Epub 2011 Jun 15. Assay Drug Dev Technol. 2011. PMID: 21675872

4

A novel series of pyrazolylpiperidine N-type calcium channel blockers.

Subasinghe NL, Wall MJ, Winters MP, Qin N, Lubin ML, Finley MF, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z. Subasinghe NL, et al. Among authors: flores cm. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4080-3. doi: 10.1016/j.bmcl.2012.04.075. Epub 2012 May 2. Bioorg Med Chem Lett. 2012. PMID: 22608964

5

Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel.

Winters MP, Subasinghe N, Wall M, Beck E, Brandt MR, Finley MF, Liu Y, Lubin ML, Neeper MP, Qin N, Flores CM, Sui Z. Winters MP, et al. Among authors: flores cm. Bioorg Med Chem Lett. 2014 May 1;24(9):2053-6. doi: 10.1016/j.bmcl.2014.03.062. Epub 2014 Mar 27. Bioorg Med Chem Lett. 2014. PMID: 24726802

6

Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors.

Winters MP, Subasinghe N, Wall M, Beck E, Brandt MR, Finley MF, Liu Y, Lubin ML, Neeper MP, Qin N, Flores CM, Sui Z. Winters MP, et al. Among authors: flores cm. Bioorg Med Chem Lett. 2014 May 1;24(9):2057-61. doi: 10.1016/j.bmcl.2014.03.063. Epub 2014 Mar 28. Bioorg Med Chem Lett. 2014. PMID: 24726803

7

Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Ca_v 2.2) blockers for the treatment of pain.

Wall MJ, Subasinghe NL, Winters MP, Lubin ML, Finley MFA, Qin N, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z. Wall MJ, et al. Among authors: flores cm. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3780-3783. doi: 10.1016/j.bmcl.2018.10.007. Epub 2018 Oct 12. Bioorg Med Chem Lett. 2018. PMID: 30337231

8

A nonadherent cell-based HTS assay for N-type calcium channel using calcium 3 dye.

Lubin ML, Reitz TL, Todd MJ, Flores CM, Qin N, Xin H. Lubin ML, et al. Among authors: flores cm. Assay Drug Dev Technol. 2006 Dec;4(6):689-94. doi: 10.1089/adt.2006.4.689. Assay Drug Dev Technol. 2006. PMID: 17199507

9

TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons.

Qin N, Neeper MP, Liu Y, Hutchinson TL, Lubin ML, Flores CM. Qin N, et al. Among authors: flores cm. J Neurosci. 2008 Jun 11;28(24):6231-8. doi: 10.1523/JNEUROSCI.0504-08.2008. J Neurosci. 2008. PMID: 18550765 Free PMC article.

10

Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.

Parks DJ, Parsons WH, Colburn RW, Meegalla SK, Ballentine SK, Illig CR, Qin N, Liu Y, Hutchinson TL, Lubin ML, Stone DJ Jr, Baker JF, Schneider CR, Ma J, Damiano BP, Flores CM, Player MR. Parks DJ, et al. Among authors: flores cm. J Med Chem. 2011 Jan 13;54(1):233-47. doi: 10.1021/jm101075v. Epub 2010 Dec 3. J Med Chem. 2011. PMID: 21128593

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