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Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14.
Marr N, Hajjar AM, Shah NR, Novikov A, Yam CS, Caroff M, Fernandez RC. Marr N, et al. Among authors: fernandez rc. Infect Immun. 2010 May;78(5):2060-9. doi: 10.1128/IAI.01346-09. Epub 2010 Feb 22. Infect Immun. 2010. PMID: 20176798 Free PMC article.
Minor modifications to the phosphate groups and the C3' acyl chain length of lipid A in two Bordetella pertussis strains, BP338 and 18-323, independently affect Toll-like receptor 4 protein activation.
Shah NR, Albitar-Nehme S, Kim E, Marr N, Novikov A, Caroff M, Fernandez RC. Shah NR, et al. Among authors: fernandez rc. J Biol Chem. 2013 Apr 26;288(17):11751-60. doi: 10.1074/jbc.M112.434365. Epub 2013 Mar 6. J Biol Chem. 2013. PMID: 23467413 Free PMC article.
80 results