Lippens G - Search Results

1

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A.

Coelmont L, Hanoulle X, Chatterji U, Berger C, Snoeck J, Bobardt M, Lim P, Vliegen I, Paeshuyse J, Vuagniaux G, Vandamme AM, Bartenschlager R, Gallay P, Lippens G, Neyts J. Coelmont L, et al. Among authors: lippens g. PLoS One. 2010 Oct 27;5(10):e13687. doi: 10.1371/journal.pone.0013687. PLoS One. 2010. PMID: 21060866 Free PMC article.

2

Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.

Verdegem D, Badillo A, Wieruszeski JM, Landrieu I, Leroy A, Bartenschlager R, Penin F, Lippens G, Hanoulle X. Verdegem D, et al. Among authors: lippens g. J Biol Chem. 2011 Jun 10;286(23):20441-54. doi: 10.1074/jbc.M110.182436. Epub 2011 Apr 13. J Biol Chem. 2011. PMID: 21489988 Free PMC article.

3

Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B.

Hanoulle X, Badillo A, Wieruszeski JM, Verdegem D, Landrieu I, Bartenschlager R, Penin F, Lippens G. Hanoulle X, et al. Among authors: lippens g. J Biol Chem. 2009 May 15;284(20):13589-13601. doi: 10.1074/jbc.M809244200. Epub 2009 Mar 18. J Biol Chem. 2009. PMID: 19297321 Free PMC article.

4

A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication.

Dujardin M, Madan V, Montserret R, Ahuja P, Huvent I, Launay H, Leroy A, Bartenschlager R, Penin F, Lippens G, Hanoulle X. Dujardin M, et al. Among authors: lippens g. J Biol Chem. 2015 Jul 31;290(31):19104-20. doi: 10.1074/jbc.M115.644419. Epub 2015 Jun 17. J Biol Chem. 2015. PMID: 26085105 Free PMC article.

5

Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A.

Rosnoblet C, Fritzinger B, Legrand D, Launay H, Wieruszeski JM, Lippens G, Hanoulle X. Rosnoblet C, et al. Among authors: lippens g. J Biol Chem. 2012 Dec 28;287(53):44249-60. doi: 10.1074/jbc.M112.392209. Epub 2012 Nov 14. J Biol Chem. 2012. PMID: 23152499 Free PMC article.

6

Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A.

Badillo A, Receveur-Brechot V, Sarrazin S, Cantrelle FX, Delolme F, Fogeron ML, Molle J, Montserret R, Bockmann A, Bartenschlager R, Lohmann V, Lippens G, Ricard-Blum S, Hanoulle X, Penin F. Badillo A, et al. Among authors: lippens g. Biochemistry. 2017 Jun 20;56(24):3029-3048. doi: 10.1021/acs.biochem.7b00212. Epub 2017 Jun 7. Biochemistry. 2017. PMID: 28535337

7

Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication.

Dujardin M, Madan V, Gandhi NS, Cantrelle FX, Launay H, Huvent I, Bartenschlager R, Lippens G, Hanoulle X. Dujardin M, et al. Among authors: lippens g. J Biol Chem. 2019 Aug 30;294(35):13171-13185. doi: 10.1074/jbc.RA119.009537. Epub 2019 Jul 17. J Biol Chem. 2019. PMID: 31315928 Free PMC article.

8

Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025.

Landrieu I, Hanoulle X, Bonachera F, Hamel A, Sibille N, Yin Y, Wieruszeski JM, Horvath D, Wei Q, Vuagniaux G, Lippens G. Landrieu I, et al. Among authors: lippens g. Biochemistry. 2010 Jun 8;49(22):4679-86. doi: 10.1021/bi1003266. Biochemistry. 2010. PMID: 20423153

9

The domain 2 of the HCV NS5A protein is intrinsically unstructured.

Hanoulle X, Badillo A, Verdegem D, Penin F, Lippens G. Hanoulle X, et al. Among authors: lippens g. Protein Pept Lett. 2010 Aug;17(8):1012-8. doi: 10.2174/092986610791498920. Protein Pept Lett. 2010. PMID: 20450484

10

Dissociation kinetics of a binary complex in solution by protein displacement.

Launay H, Parent B, Page A, Hanoulle X, Lippens G. Launay H, et al. Among authors: lippens g. Angew Chem Int Ed Engl. 2013 Nov 25;52(48):12587-91. doi: 10.1002/anie.201306253. Epub 2013 Oct 7. Angew Chem Int Ed Engl. 2013. PMID: 24123878 No abstract available.

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