Bissada N - Search Results

1

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

Graham RK, Deng Y, Carroll J, Vaid K, Cowan C, Pouladi MA, Metzler M, Bissada N, Wang L, Faull RL, Gray M, Yang XW, Raymond LA, Hayden MR. Graham RK, et al. Among authors: bissada n. J Neurosci. 2010 Nov 10;30(45):15019-29. doi: 10.1523/JNEUROSCI.2071-10.2010. J Neurosci. 2010. PMID: 21068307 Free PMC article.

2

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.

Slow EJ, Graham RK, Osmand AP, Devon RS, Lu G, Deng Y, Pearson J, Vaid K, Bissada N, Wetzel R, Leavitt BR, Hayden MR. Slow EJ, et al. Among authors: bissada n. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11402-7. doi: 10.1073/pnas.0503634102. Epub 2005 Aug 2. Proc Natl Acad Sci U S A. 2005. PMID: 16076956 Free PMC article.

3

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.

Graham RK, Slow EJ, Deng Y, Bissada N, Lu G, Pearson J, Shehadeh J, Leavitt BR, Raymond LA, Hayden MR. Graham RK, et al. Among authors: bissada n. Neurobiol Dis. 2006 Feb;21(2):444-55. doi: 10.1016/j.nbd.2005.08.007. Epub 2005 Oct 17. Neurobiol Dis. 2006. PMID: 16230019

4

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR. Graham RK, et al. Among authors: bissada n. Cell. 2006 Jun 16;125(6):1179-91. doi: 10.1016/j.cell.2006.04.026. Cell. 2006. PMID: 16777606 Free article.

5

NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1.

Metzler M, Gan L, Wong TP, Liu L, Helm J, Liu L, Georgiou J, Wang Y, Bissada N, Cheng K, Roder JC, Wang YT, Hayden MR. Metzler M, et al. Among authors: bissada n. J Neurosci. 2007 Feb 28;27(9):2298-308. doi: 10.1523/JNEUROSCI.5175-06.2007. J Neurosci. 2007. PMID: 17329427 Free PMC article.

6

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.

Pouladi MA, Xie Y, Skotte NH, Ehrnhoefer DE, Graham RK, Kim JE, Bissada N, Yang XW, Paganetti P, Friedlander RM, Leavitt BR, Hayden MR. Pouladi MA, et al. Among authors: bissada n. Hum Mol Genet. 2010 Apr 15;19(8):1528-38. doi: 10.1093/hmg/ddq026. Epub 2010 Jan 22. Hum Mol Genet. 2010. PMID: 20097678 Free PMC article.

7

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

Metzler M, Gan L, Mazarei G, Graham RK, Liu L, Bissada N, Lu G, Leavitt BR, Hayden MR. Metzler M, et al. Among authors: bissada n. J Neurosci. 2010 Oct 27;30(43):14318-29. doi: 10.1523/JNEUROSCI.1589-10.2010. J Neurosci. 2010. PMID: 20980587 Free PMC article.

8

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.

Uribe V, Wong BK, Graham RK, Cusack CL, Skotte NH, Pouladi MA, Xie Y, Feinberg K, Ou Y, Ouyang Y, Deng Y, Franciosi S, Bissada N, Spreeuw A, Zhang W, Ehrnhoefer DE, Vaid K, Miller FD, Deshmukh M, Howland D, Hayden MR. Uribe V, et al. Among authors: bissada n. Hum Mol Genet. 2012 May 1;21(9):1954-67. doi: 10.1093/hmg/dds005. Epub 2012 Jan 18. Hum Mol Genet. 2012. PMID: 22262731 Free PMC article.

9

Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo.

Graham RK, Deng Y, Pouladi MA, Vaid K, Ehrnhoefer D, Southwell AL, Bissada N, Franciosi S, Hayden MR. Graham RK, et al. Among authors: bissada n. J Huntingtons Dis. 2012;1(2):243-60. doi: 10.3233/JHD-120038. J Huntingtons Dis. 2012. PMID: 25063333

10

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.

Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. Slow EJ, et al. Among authors: bissada n. Hum Mol Genet. 2003 Jul 1;12(13):1555-67. doi: 10.1093/hmg/ddg169. Hum Mol Genet. 2003. PMID: 12812983

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