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Page 1
Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor.
Moffat D, Patel S, Day F, Belfield A, Donald A, Rowlands M, Wibawa J, Brotherton D, Stimson L, Clark V, Owen J, Bawden L, Box G, Bone E, Mortenson P, Hardcastle A, van Meurs S, Eccles S, Raynaud F, Aherne W. Moffat D, et al. Among authors: stimson l. J Med Chem. 2010 Dec 23;53(24):8663-78. doi: 10.1021/jm101177s. Epub 2010 Nov 16. J Med Chem. 2010. PMID: 21080647
Design and synthesis of novel pyrimidine hydroxamic acid inhibitors of histone deacetylases.
Donald AD, Clark VL, Patel S, Day FA, Rowlands MG, Wibata J, Stimson L, Hardcastle A, Eccles SA, McNamara D, Needham LA, Raynaud FI, Aherne W, Moffat DF. Donald AD, et al. Among authors: stimson l. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6657-60. doi: 10.1016/j.bmcl.2010.09.016. Epub 2010 Sep 21. Bioorg Med Chem Lett. 2010. PMID: 20884208
Histone modification enzymes: novel targets for cancer drugs.
Kristeleit R, Stimson L, Workman P, Aherne W. Kristeleit R, et al. Among authors: stimson l. Expert Opin Emerg Drugs. 2004 May;9(1):135-54. doi: 10.1517/eoed.9.1.135.32947. Expert Opin Emerg Drugs. 2004. PMID: 15155140 Review.
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity.
Stimson L, Rowlands MG, Newbatt YM, Smith NF, Raynaud FI, Rogers P, Bavetsias V, Gorsuch S, Jarman M, Bannister A, Kouzarides T, McDonald E, Workman P, Aherne GW. Stimson L, et al. Mol Cancer Ther. 2005 Oct;4(10):1521-32. doi: 10.1158/1535-7163.MCT-05-0135. Mol Cancer Ther. 2005. PMID: 16227401
Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
Maloney A, Clarke PA, Naaby-Hansen S, Stein R, Koopman JO, Akpan A, Yang A, Zvelebil M, Cramer R, Stimson L, Aherne W, Banerji U, Judson I, Sharp S, Powers M, deBilly E, Salmons J, Walton M, Burlingame A, Waterfield M, Workman P. Maloney A, et al. Among authors: stimson l. Cancer Res. 2007 Apr 1;67(7):3239-53. doi: 10.1158/0008-5472.CAN-06-2968. Cancer Res. 2007. PMID: 17409432
HDAC inhibitor-based therapies and haematological malignancy.
Stimson L, Wood V, Khan O, Fotheringham S, La Thangue NB. Stimson L, et al. Ann Oncol. 2009 Aug;20(8):1293-302. doi: 10.1093/annonc/mdn792. Epub 2009 Jun 10. Ann Oncol. 2009. PMID: 19515748 Free article. Review.
HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy.
Khan O, Fotheringham S, Wood V, Stimson L, Zhang C, Pezzella F, Duvic M, Kerr DJ, La Thangue NB. Khan O, et al. Among authors: stimson l. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6532-7. doi: 10.1073/pnas.0913912107. Epub 2010 Mar 22. Proc Natl Acad Sci U S A. 2010. PMID: 20308564 Free PMC article.
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