Pak Y - Search Results

1

PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model.

Reilly MP, Sinha U, André P, Taylor SM, Pak Y, Deguzman FR, Nanda N, Pandey A, Stolla M, Bergmeier W, McKenzie SE. Reilly MP, et al. Among authors: pak y. Blood. 2011 Feb 17;117(7):2241-6. doi: 10.1182/blood-2010-03-274969. Epub 2010 Nov 18. Blood. 2011. PMID: 21088136 Free PMC article.

2

The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia.

Spurgeon SE, Coffey G, Fletcher LB, Burke R, Tyner JW, Druker BJ, Betz A, DeGuzman F, Pak Y, Baker D, Pandey A, Hollenbach SJ, Sinha U, Loriaux MM. Spurgeon SE, et al. Among authors: pak y. J Pharmacol Exp Ther. 2013 Feb;344(2):378-87. doi: 10.1124/jpet.112.200832. Epub 2012 Dec 7. J Pharmacol Exp Ther. 2013. PMID: 23220742 Free PMC article.

3

Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis.

Coffey G, DeGuzman F, Inagaki M, Pak Y, Delaney SM, Ives D, Betz A, Jia ZJ, Pandey A, Baker D, Hollenbach SJ, Phillips DR, Sinha U. Coffey G, et al. Among authors: pak y. J Pharmacol Exp Ther. 2012 Feb;340(2):350-9. doi: 10.1124/jpet.111.188441. Epub 2011 Oct 31. J Pharmacol Exp Ther. 2012. PMID: 22040680

4

The novel kinase inhibitor PRT062070 (Cerdulatinib) demonstrates efficacy in models of autoimmunity and B-cell cancer.

Coffey G, Betz A, DeGuzman F, Pak Y, Inagaki M, Baker DC, Hollenbach SJ, Pandey A, Sinha U. Coffey G, et al. Among authors: pak y. J Pharmacol Exp Ther. 2014 Dec;351(3):538-48. doi: 10.1124/jpet.114.218164. Epub 2014 Sep 24. J Pharmacol Exp Ther. 2014. PMID: 25253883

5

PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers.

Coffey G, Rani A, Betz A, Pak Y, Haberstock-Debic H, Pandey A, Hollenbach S, Gretler DD, Mant T, Jurcevic S, Sinha U. Coffey G, et al. Among authors: pak y. J Clin Pharmacol. 2017 Feb;57(2):194-210. doi: 10.1002/jcph.794. Epub 2016 Aug 17. J Clin Pharmacol. 2017. PMID: 27406873 Free PMC article.

6

Thienopyridines, but not elinogrel, result in off-target effects at the vessel wall that contribute to bleeding.

André P, DeGuzman F, Haberstock-Debic H, Mills S, Pak Y, Inagaki M, Pandey A, Hollenbach S, Phillips DR, Conley PB. André P, et al. Among authors: pak y. J Pharmacol Exp Ther. 2011 Jul;338(1):22-30. doi: 10.1124/jpet.110.178574. Epub 2011 Mar 29. J Pharmacol Exp Ther. 2011. PMID: 21447613

7

Evaluation of a minimal experimental design for determination of enzyme kinetic parameters and inhibition mechanism.

Kakkar T, Pak Y, Mayersohn M. Kakkar T, et al. Among authors: pak y. J Pharmacol Exp Ther. 2000 Jun;293(3):861-9. J Pharmacol Exp Ther. 2000. PMID: 10869386

8

Protein expression pattern of P-glycoprotein along the gastrointestinal tract of the Yucatan micropig.

Tang H, Pak Y, Mayersohn M. Tang H, et al. Among authors: pak y. J Biochem Mol Toxicol. 2004;18(1):18-22. doi: 10.1002/jbt.20001. J Biochem Mol Toxicol. 2004. PMID: 14994275

9

Characterization of the properties of cocaine in blood: blood clearance, blood to plasma ratio, and plasma protein binding.

Sukbuntherng J, Martin DK, Pak Y, Mayersohn M. Sukbuntherng J, et al. Among authors: pak y. J Pharm Sci. 1996 Jun;85(6):567-71. doi: 10.1021/js960026h. J Pharm Sci. 1996. PMID: 8773950

10

Sensitive and rapid isocratic liquid chromatography method for the quantitation of curcumin in plasma.

Pak Y, Patek R, Mayersohn M. Pak Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Nov 5;796(2):339-46. doi: 10.1016/j.jchromb.2003.08.018. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 14581073

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