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Page 1
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.
Godlewski G, Alapafuja SO, Bátkai S, Nikas SP, Cinar R, Offertáler L, Osei-Hyiaman D, Liu J, Mukhopadhyay B, Harvey-White J, Tam J, Pacak K, Blankman JL, Cravatt BF, Makriyannis A, Kunos G. Godlewski G, et al. Among authors: alapafuja so. Chem Biol. 2010 Nov 24;17(11):1256-66. doi: 10.1016/j.chembiol.2010.08.013. Chem Biol. 2010. PMID: 21095576 Free PMC article.
Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats.
Panlilio LV, Thorndike EB, Nikas SP, Alapafuja SO, Bandiera T, Cravatt BF, Makriyannis A, Piomelli D, Goldberg SR, Justinova Z. Panlilio LV, et al. Among authors: alapafuja so. Psychopharmacology (Berl). 2016 May;233(10):1879-88. doi: 10.1007/s00213-015-4140-6. Epub 2015 Nov 12. Psychopharmacology (Berl). 2016. PMID: 26558620 Free PMC article.
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice.
Bashashati M, Storr MA, Nikas SP, Wood JT, Godlewski G, Liu J, Ho W, Keenan CM, Zhang H, Alapafuja SO, Cravatt BF, Lutz B, Mackie K, Kunos G, Patel KD, Makriyannis A, Davison JS, Sharkey KA. Bashashati M, et al. Among authors: alapafuja so. Br J Pharmacol. 2012 Mar;165(5):1556-71. doi: 10.1111/j.1476-5381.2011.01644.x. Br J Pharmacol. 2012. PMID: 21883147 Free PMC article.
Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.
Gunduz-Cinar O, MacPherson KP, Cinar R, Gamble-George J, Sugden K, Williams B, Godlewski G, Ramikie TS, Gorka AX, Alapafuja SO, Nikas SP, Makriyannis A, Poulton R, Patel S, Hariri AR, Caspi A, Moffitt TE, Kunos G, Holmes A. Gunduz-Cinar O, et al. Among authors: alapafuja so. Mol Psychiatry. 2013 Jul;18(7):813-23. doi: 10.1038/mp.2012.72. Epub 2012 Jun 12. Mol Psychiatry. 2013. PMID: 22688188 Free PMC article.
Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.
Alapafuja SO, Nikas SP, Bharathan IT, Shukla VG, Nasr ML, Bowman AL, Zvonok N, Li J, Shi X, Engen JR, Makriyannis A. Alapafuja SO, et al. J Med Chem. 2012 Nov 26;55(22):10074-89. doi: 10.1021/jm301205j. Epub 2012 Nov 2. J Med Chem. 2012. PMID: 23083016 Free PMC article.
C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.
Papahatjis DP, Nahmias VR, Nikas SP, Andreou T, Alapafuja SO, Tsotinis A, Guo J, Fan P, Makriyannis A. Papahatjis DP, et al. Among authors: alapafuja so. J Med Chem. 2007 Aug 23;50(17):4048-60. doi: 10.1021/jm070121a. Epub 2007 Aug 2. J Med Chem. 2007. PMID: 17672444
Novel 1',1'-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist.
Nikas SP, Alapafuja SO, Papanastasiou I, Paronis CA, Shukla VG, Papahatjis DP, Bowman AL, Halikhedkar A, Han X, Makriyannis A. Nikas SP, et al. Among authors: alapafuja so. J Med Chem. 2010 Oct 14;53(19):6996-7010. doi: 10.1021/jm100641g. J Med Chem. 2010. PMID: 20925434 Free PMC article.
16 results