Goc A - Search Results

1

PI3 kinase integrates Akt and MAP kinase signaling pathways in the regulation of prostate cancer.

Goc A, Al-Husein B, Kochuparambil ST, Liu J, Heston WW, Somanath PR. Goc A, et al. Int J Oncol. 2011 Jan;38(1):267-77. Int J Oncol. 2011. PMID: 21109949

2

Akt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β₃ affinity modulation.

Goc A, Liu J, Byzova TV, Somanath PR. Goc A, et al. Br J Cancer. 2012 Aug 7;107(4):713-23. doi: 10.1038/bjc.2012.295. Epub 2012 Jul 5. Br J Cancer. 2012. PMID: 22767145 Free PMC article.

3

Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression.

Kochuparambil ST, Al-Husein B, Goc A, Soliman S, Somanath PR. Kochuparambil ST, et al. Among authors: goc a. J Pharmacol Exp Ther. 2011 Feb;336(2):496-505. doi: 10.1124/jpet.110.174870. Epub 2010 Nov 8. J Pharmacol Exp Ther. 2011. PMID: 21059805

4

TGFβ- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR).

Goc A, Choudhary M, Byzova TV, Somanath PR. Goc A, et al. J Cell Physiol. 2011 Nov;226(11):3004-13. doi: 10.1002/jcp.22648. J Cell Physiol. 2011. PMID: 21302298 Free PMC article.

5

Rac1 activation driven by 14-3-3ζ dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migration.

Goc A, Abdalla M, Al-Azayzih A, Somanath PR. Goc A, et al. PLoS One. 2012;7(7):e40594. doi: 10.1371/journal.pone.0040594. Epub 2012 Jul 13. PLoS One. 2012. PMID: 22808202 Free PMC article.

6

Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis.

Goc A, Kochuparambil ST, Al-Husein B, Al-Azayzih A, Mohammad S, Somanath PR. Goc A, et al. BMC Cancer. 2012 Sep 14;12:409. doi: 10.1186/1471-2407-12-409. BMC Cancer. 2012. PMID: 22974127 Free PMC article.

7

TGFβ1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspases.

Al-Azayzih A, Gao F, Goc A, Somanath PR. Al-Azayzih A, et al. Among authors: goc a. Biochem Biophys Res Commun. 2012 Oct 12;427(1):165-70. doi: 10.1016/j.bbrc.2012.09.035. Epub 2012 Sep 16. Biochem Biophys Res Commun. 2012. PMID: 22989755 Free PMC article.

8

P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion.

Goc A, Al-Azayzih A, Abdalla M, Al-Husein B, Kavuri S, Lee J, Moses K, Somanath PR. Goc A, et al. J Biol Chem. 2013 Feb 1;288(5):3025-35. doi: 10.1074/jbc.M112.424770. Epub 2012 Dec 20. J Biol Chem. 2013. PMID: 23258534 Free PMC article.

9

Suppression of interactions between prostate tumor cell-surface integrin and endothelial ICAM-1 by simvastatin inhibits micrometastasis.

Al-Husein B, Goc A, Somanath PR. Al-Husein B, et al. Among authors: goc a. J Cell Physiol. 2013 Nov;228(11):2139-48. doi: 10.1002/jcp.24381. J Cell Physiol. 2013. PMID: 23559257 Free PMC article.

10

Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo.

Goc A, Al-Husein B, Katsanevas K, Steinbach A, Lou U, Sabbineni H, DeRemer DL, Somanath PR. Goc A, et al. Oncotarget. 2014 Feb 15;5(3):775-87. doi: 10.18632/oncotarget.1770. Oncotarget. 2014. PMID: 24519956 Free PMC article.

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