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Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines.
Simoni D, Grisolia G, Giannini G, Roberti M, Rondanin R, Piccagli L, Baruchello R, Rossi M, Romagnoli R, Invidiata FP, Grimaudo S, Jung MK, Hamel E, Gebbia N, Crosta L, Abbadessa V, Di Cristina A, Dusonchet L, Meli M, Tolomeo M. Simoni D, et al. Among authors: tolomeo m. J Med Chem. 2005 Feb 10;48(3):723-36. doi: 10.1021/jm049622b. J Med Chem. 2005. PMID: 15689156
Synthesis and antiproliferative activity of 3-amino-N-phenyl-1H-indazole-1-carboxamides.
Raffa D, Maggio B, Cascioferro S, Raimondi MV, Schillaci D, Gallo G, Daidone G, Plescia S, Meneghetti F, Bombieri G, Di Cristina A, Pipitone RM, Grimaudo S, Tolomeo M. Raffa D, et al. Among authors: tolomeo m. Eur J Med Chem. 2009 Jan;44(1):165-78. doi: 10.1016/j.ejmech.2008.03.023. Epub 2008 Apr 8. Eur J Med Chem. 2009. PMID: 18485541
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Romagnoli R, Baraldi PG, Carrion MD, Cruz-Lopez O, Cara CL, Tolomeo M, Grimaudo S, Di Cristina A, Pipitone MR, Balzarini J, Kandil S, Brancale A, Sarkar T, Hamel E. Romagnoli R, et al. Among authors: tolomeo m. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5041-5. doi: 10.1016/j.bmcl.2008.08.006. Epub 2008 Aug 6. Bioorg Med Chem Lett. 2008. PMID: 18725179 Free PMC article.
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.
Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Tolomeo M, Grimaudo S, Di Cristina A, Pipitone MR, Balzarini J, Zonta N, Brancale A, Hamel E. Romagnoli R, et al. Among authors: tolomeo m. Bioorg Med Chem. 2009 Oct 1;17(19):6862-71. doi: 10.1016/j.bmc.2009.08.027. Epub 2009 Aug 20. Bioorg Med Chem. 2009. PMID: 19736015 Free PMC article.
115 results