Chen W - Search Results

1

Design, synthesis, and biological evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine and its analogs as a novel class of anticancer agents.

Chen W, Seefeldt T, Young A, Zhang X, Guan X. Chen W, et al. Bioorg Med Chem. 2011 Jan 1;19(1):287-94. doi: 10.1016/j.bmc.2010.11.026. Epub 2010 Nov 13. Bioorg Med Chem. 2011. PMID: 21131205 Free PMC article.

2

Evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine as an irreversible inhibitor of mammalian thioredoxin reductase1.

Chen W, Jiang Z, Lin N, Zheng Z, Chen Z, Zhang X, Guan X. Chen W, et al. Among authors: chen z. J Enzyme Inhib Med Chem. 2016;31(2):229-35. doi: 10.3109/14756366.2015.1016512. Epub 2015 Mar 17. J Enzyme Inhib Med Chem. 2016. PMID: 25778746 Free article.

3

Microtubule S-glutathionylation as a potential approach for antimitotic agents.

Chen W, Seefeldt T, Young A, Zhang X, Zhao Y, Ruffolo J, Kaushik RS, Guan X. Chen W, et al. BMC Cancer. 2012 Jun 15;12:245. doi: 10.1186/1471-2407-12-245. BMC Cancer. 2012. PMID: 22703118 Free PMC article.

4

Determination of thiols and disulfides via HPLC quantification of 5-thio-2-nitrobenzoic acid.

Chen W, Zhao Y, Seefeldt T, Guan X. Chen W, et al. J Pharm Biomed Anal. 2008 Dec 15;48(5):1375-80. doi: 10.1016/j.jpba.2008.08.033. Epub 2008 Sep 7. J Pharm Biomed Anal. 2008. PMID: 18926658 Free PMC article.

5

Characterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione.

Seefeldt T, Zhao Y, Chen W, Raza AS, Carlson L, Herman J, Stoebner A, Hanson S, Foll R, Guan X. Seefeldt T, et al. Among authors: chen w. J Biol Chem. 2009 Jan 30;284(5):2729-2737. doi: 10.1074/jbc.M802683200. Epub 2008 Dec 2. J Biol Chem. 2009. PMID: 19049979 Free PMC article.

6

N‑acetyl-S-(p-chlorophenylcarbamoyl)cysteine induces mitochondrial-mediated apoptosis and suppresses migration in melanoma cells.

Chen W, Jiang Z, Zhang X, Feng J, Ling Y. Chen W, et al. Oncol Rep. 2015 Nov;34(5):2547-56. doi: 10.3892/or.2015.4267. Epub 2015 Sep 9. Oncol Rep. 2015. PMID: 26351874

7

Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation.

Zhao Y, Seefeldt T, Chen W, Carlson L, Stoebner A, Hanson S, Foll R, Matthees DP, Palakurthi S, Guan X. Zhao Y, et al. Among authors: chen w. Free Radic Biol Med. 2009 Jul 15;47(2):176-83. doi: 10.1016/j.freeradbiomed.2009.04.022. Epub 2009 Apr 24. Free Radic Biol Med. 2009. PMID: 19397999 Free PMC article.

8

Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells.

Zhang X, Chen W, Guillermo R, Chandrasekher G, Kaushik RS, Young A, Fahmy H, Dwivedi C. Zhang X, et al. Among authors: chen w. BMC Res Notes. 2010 Aug 3;3:220. doi: 10.1186/1756-0500-3-220. BMC Res Notes. 2010. PMID: 20682067 Free PMC article.

9

Effects of glutathione reductase inhibition on cellular thiol redox state and related systems.

Zhao Y, Seefeldt T, Chen W, Wang X, Matthees D, Hu Y, Guan X. Zhao Y, et al. Among authors: chen w. Arch Biochem Biophys. 2009 May 1;485(1):56-62. doi: 10.1016/j.abb.2009.03.001. Epub 2009 Mar 9. Arch Biochem Biophys. 2009. PMID: 19272349 Free PMC article.

10

Sarcophine-diol, a Chemopreventive Agent of Skin Cancer, Inhibits Cell Growth and Induces Apoptosis through Extrinsic Pathway in Human Epidermoid Carcinoma A431 Cells.

Zhang X, Bommareddy A, Chen W, Khalifa S, Kaushik RS, Fahmy H, Dwivedi C. Zhang X, et al. Among authors: chen w. Transl Oncol. 2009 Mar;2(1):21-30. doi: 10.1593/tlo.08190. Transl Oncol. 2009. PMID: 19252748 Free PMC article.

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