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CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis.
Wang Y, Li J, Cui Y, Li T, Ng KM, Geng H, Li H, Shu XS, Li H, Liu W, Luo B, Zhang Q, Mok TS, Zheng W, Qiu X, Srivastava G, Yu J, Sung JJ, Chan AT, Ma D, Tao Q, Han W. Wang Y, et al. Among authors: li t, li j, li h. Cancer Res. 2009 Jun 15;69(12):5194-201. doi: 10.1158/0008-5472.CAN-08-3694. Epub 2009 Jun 9. Cancer Res. 2009. PMID: 19509237
CMTM3 presents a secreted form released via exosomes.
Liu B, Li H, Fu W, Cheng Y, Yuan W, Liu W, Xue H, Mo X. Liu B, et al. Among authors: li h. Acta Biochim Biophys Sin (Shanghai). 2016 Jun;48(6):584-6. doi: 10.1093/abbs/gmw029. Epub 2016 Apr 28. Acta Biochim Biophys Sin (Shanghai). 2016. PMID: 27125975 Free PMC article. No abstract available.
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