Yoshimura Y - Search Results

1

The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors.

Natori Y, Imahori T, Murakami K, Yoshimura Y, Nakagawa S, Kato A, Adachi I, Takahata H. Natori Y, et al. Among authors: yoshimura y. Bioorg Med Chem Lett. 2011 Jan 15;21(2):738-41. doi: 10.1016/j.bmcl.2010.11.112. Epub 2010 Nov 30. Bioorg Med Chem Lett. 2011. PMID: 21185187

2

A straightforward stereoselective synthesis of meso-, (S,S)- and (R,R)-2,6-diaminopimelic acids from cis-1,4-diacetoxycyclohept-2-ene.

Saito Y, Shinkai T, Yoshimura Y, Takahata H. Saito Y, et al. Among authors: yoshimura y. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5894-6. doi: 10.1016/j.bmcl.2007.07.106. Epub 2007 Aug 26. Bioorg Med Chem Lett. 2007. PMID: 17826999

3

Synthesis of all stereoisomers of 3-hydroxypipecolic acid and 3-hydroxy-4,5-dehydropipecolic acid and their evaluation as glycosidase inhibitors.

Ohara C, Takahashi R, Miyagawa T, Yoshimura Y, Kato A, Adachi I, Takahata H. Ohara C, et al. Among authors: yoshimura y. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1810-3. doi: 10.1016/j.bmcl.2008.02.028. Epub 2008 Feb 14. Bioorg Med Chem Lett. 2008. PMID: 18296050

4

Synthesis of both enantiomers of hydroxypipecolic acid derivatives equivalent to 5-azapyranuronic acids and evaluation of their inhibitory activities against glycosidases.

Yoshimura Y, Ohara C, Imahori T, Saito Y, Kato A, Miyauchi S, Adachi I, Takahata H. Yoshimura Y, et al. Bioorg Med Chem. 2008 Sep 1;16(17):8273-86. doi: 10.1016/j.bmc.2008.06.016. Epub 2008 Jun 13. Bioorg Med Chem. 2008. PMID: 18703340

5

Synthesis of 5-thiodidehydropyranylcytosine derivatives as potential anti-HIV agents.

Yoshimura Y, Yamazaki Y, Saito Y, Natori Y, Imamichi T, Takahata H. Yoshimura Y, et al. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3313-6. doi: 10.1016/j.bmcl.2011.04.006. Epub 2011 Apr 9. Bioorg Med Chem Lett. 2011. PMID: 21524575

6

Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors.

Kato A, Miyauchi S, Kato N, Nash RJ, Yoshimura Y, Nakagome I, Hirono S, Takahata H, Adachi I. Kato A, et al. Among authors: yoshimura y. Bioorg Med Chem. 2011 Jun 1;19(11):3558-68. doi: 10.1016/j.bmc.2011.04.011. Epub 2011 Apr 13. Bioorg Med Chem. 2011. PMID: 21546253

7

α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.

Kato A, Hayashi E, Miyauchi S, Adachi I, Imahori T, Natori Y, Yoshimura Y, Nash RJ, Shimaoka H, Nakagome I, Koseki J, Hirono S, Takahata H. Kato A, et al. Among authors: yoshimura y. J Med Chem. 2012 Dec 13;55(23):10347-62. doi: 10.1021/jm301304e. Epub 2012 Nov 19. J Med Chem. 2012. PMID: 23106358

8

Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.

Natori Y, Sakuma T, Yoshimura Y, Kinami K, Hirokami Y, Sato K, Adachi I, Kato A, Takahata H. Natori Y, et al. Among authors: yoshimura y. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3298-301. doi: 10.1016/j.bmcl.2014.06.001. Epub 2014 Jun 11. Bioorg Med Chem Lett. 2014. PMID: 24973028

9

New synthesis of (+/-)-isonucleosides.

Yoshimura Y, Asami K, Matsui H, Tanaka H, Takahata H. Yoshimura Y, et al. Org Lett. 2006 Dec 21;8(26):6015-8. doi: 10.1021/ol062491j. Org Lett. 2006. PMID: 17165918

10

A new entry to carbocyclic nucleosides: oxidative coupling reaction of cycloalkenylsilanes with a nucleobase mediated by hypervalent iodine reagent.

Yoshimura Y, Ohta M, Imahori T, Imamichi T, Takahata H. Yoshimura Y, et al. Org Lett. 2008 Aug 21;10(16):3449-52. doi: 10.1021/ol8012155. Epub 2008 Jul 10. Org Lett. 2008. PMID: 18613695

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