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Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA.
Stiborová M, Naiman K, Martínková M, Martínek V, Svobodová M, Schmeiser HH, Frei E. Stiborová M, et al. Among authors: martinek v. Interdiscip Toxicol. 2009 Mar;2(1):24-7. doi: 10.2478/v10102-009-0004-4. Interdiscip Toxicol. 2009. PMID: 21217841 Free PMC article.
Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole.
Naiman K, Dračínská H, Dračínský M, Martínková M, Martínek V, Hodek P, Stícha M, Frei E, Stiborová M. Naiman K, et al. Among authors: martinek v. Interdiscip Toxicol. 2008 Dec;1(3-4):218-24. doi: 10.2478/v10102-010-0045-8. Interdiscip Toxicol. 2008. PMID: 21218119 Free PMC article.
Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy.
Kotrbová V, Mrázová B, Moserová M, Martínek V, Hodek P, Hudeček J, Frei E, Stiborová M. Kotrbová V, et al. Among authors: martinek v. Biochem Pharmacol. 2011 Sep 15;82(6):669-80. doi: 10.1016/j.bcp.2011.06.003. Epub 2011 Jun 13. Biochem Pharmacol. 2011. PMID: 21683692
118 results