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Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
Goulder PJ, Tang Y, Brander C, Betts MR, Altfeld M, Annamalai K, Trocha A, He S, Rosenberg ES, Ogg G, O'Callaghan CA, Kalams SA, McKinney RE Jr, Mayer K, Koup RA, Pelton SI, Burchett SK, McIntosh K, Walker BD. Goulder PJ, et al. Among authors: altfeld m. J Exp Med. 2000 Dec 18;192(12):1819-32. doi: 10.1084/jem.192.12.1819. J Exp Med. 2000. PMID: 11120778 Free PMC article.
Vpr is preferentially targeted by CTL during HIV-1 infection.
Altfeld M, Addo MM, Eldridge RL, Yu XG, Thomas S, Khatri A, Strick D, Phillips MN, Cohen GB, Islam SA, Kalams SA, Brander C, Goulder PJ, Rosenberg ES, Walker BD; HIV Study Collaboration. Altfeld M, et al. J Immunol. 2001 Sep 1;167(5):2743-52. doi: 10.4049/jimmunol.167.5.2743. J Immunol. 2001. PMID: 11509618
HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha.
Lichterfeld M, Yu XG, Waring MT, Mui SK, Johnston MN, Cohen D, Addo MM, Zaunders J, Alter G, Pae E, Strick D, Allen TM, Rosenberg ES, Walker BD, Altfeld M. Lichterfeld M, et al. Among authors: altfeld m. Blood. 2004 Jul 15;104(2):487-94. doi: 10.1182/blood-2003-12-4341. Epub 2004 Apr 1. Blood. 2004. PMID: 15059848 Free article.
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
Lichterfeld M, Kaufmann DE, Yu XG, Mui SK, Addo MM, Johnston MN, Cohen D, Robbins GK, Pae E, Alter G, Wurcel A, Stone D, Rosenberg ES, Walker BD, Altfeld M. Lichterfeld M, et al. Among authors: altfeld m. J Exp Med. 2004 Sep 20;200(6):701-12. doi: 10.1084/jem.20041270. J Exp Med. 2004. PMID: 15381726 Free PMC article.
Increased natural killer cell activity in viremic HIV-1 infection.
Alter G, Malenfant JM, Delabre RM, Burgett NC, Yu XG, Lichterfeld M, Zaunders J, Altfeld M. Alter G, et al. Among authors: altfeld m. J Immunol. 2004 Oct 15;173(8):5305-11. doi: 10.4049/jimmunol.173.8.5305. J Immunol. 2004. PMID: 15470077
322 results