Whittington DA - Search Results

1

Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases.

Lombardi PM, Angell HD, Whittington DA, Flynn EF, Rajashankar KR, Christianson DW. Lombardi PM, et al. Among authors: whittington da. Biochemistry. 2011 Mar 22;50(11):1808-17. doi: 10.1021/bi101859k. Epub 2011 Jan 26. Biochemistry. 2011. PMID: 21268586 Free PMC article.

2

Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.

Gennadios HA, Whittington DA, Li X, Fierke CA, Christianson DW. Gennadios HA, et al. Among authors: whittington da. Biochemistry. 2006 Jul 4;45(26):7940-8. doi: 10.1021/bi060823m. Biochemistry. 2006. PMID: 16800620 Free PMC article.

3

Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis.

Whittington DA, Rusche KM, Shin H, Fierke CA, Christianson DW. Whittington DA, et al. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8146-50. doi: 10.1073/pnas.1432990100. Epub 2003 Jun 20. Proc Natl Acad Sci U S A. 2003. PMID: 12819349 Free PMC article.

4

Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase.

Whittington DA, Wise ML, Urbansky M, Coates RM, Croteau RB, Christianson DW. Whittington DA, et al. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15375-80. doi: 10.1073/pnas.232591099. Epub 2002 Nov 13. Proc Natl Acad Sci U S A. 2002. PMID: 12432096 Free PMC article.

5

Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.

Whittington DA, Grubb JH, Waheed A, Shah GN, Sly WS, Christianson DW. Whittington DA, et al. J Biol Chem. 2004 Feb 20;279(8):7223-8. doi: 10.1074/jbc.M310809200. Epub 2003 Dec 3. J Biol Chem. 2004. PMID: 14660577 Free article.

6

Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC.

Shin H, Gennadios HA, Whittington DA, Christianson DW. Shin H, et al. Among authors: whittington da. Bioorg Med Chem. 2007 Apr 1;15(7):2617-23. doi: 10.1016/j.bmc.2007.01.044. Epub 2007 Jan 31. Bioorg Med Chem. 2007. PMID: 17296300

7

Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV.

Kim CY, Whittington DA, Chang JS, Liao J, May JA, Christianson DW. Kim CY, et al. Among authors: whittington da. J Med Chem. 2002 Feb 14;45(4):888-93. doi: 10.1021/jm010163d. J Med Chem. 2002. PMID: 11831900

8

Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.

Whittington DA, Waheed A, Ulmasov B, Shah GN, Grubb JH, Sly WS, Christianson DW. Whittington DA, et al. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9545-50. doi: 10.1073/pnas.161301298. Epub 2001 Aug 7. Proc Natl Acad Sci U S A. 2001. PMID: 11493685 Free PMC article.

9

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.

Hernick M, Gennadios HA, Whittington DA, Rusche KM, Christianson DW, Fierke CA. Hernick M, et al. Among authors: whittington da. J Biol Chem. 2005 Apr 29;280(17):16969-78. doi: 10.1074/jbc.M413560200. Epub 2005 Feb 10. J Biol Chem. 2005. PMID: 15705580 Free article.

10

Xenon and halogenated alkanes track putative substrate binding cavities in the soluble methane monooxygenase hydroxylase.

Whittington DA, Rosenzweig AC, Frederick CA, Lippard SJ. Whittington DA, et al. Biochemistry. 2001 Mar 27;40(12):3476-82. doi: 10.1021/bi0022487. Biochemistry. 2001. PMID: 11297413

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