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Neutralizing antibodies elicited by a novel detoxified pneumolysin derivative, PlyD1, provide protection against both pneumococcal infection and lung injury.
Salha D, Szeto J, Myers L, Claus C, Sheung A, Tang M, Ljutic B, Hanwell D, Ogilvie K, Ming M, Messham B, van den Dobbelsteen G, Hopfer R, Ochs MM, Gallichan S. Salha D, et al. Among authors: ochs mm. Infect Immun. 2012 Jun;80(6):2212-20. doi: 10.1128/IAI.06348-11. Epub 2012 Apr 2. Infect Immun. 2012. PMID: 22473606 Free PMC article.
A bivalent pneumococcal histidine triad protein D-choline-binding protein A vaccine elicits functional antibodies that passively protect mice from Streptococcus pneumoniae challenge.
Ochs MM, Williams K, Sheung A, Lheritier P, Visan L, Rouleau N, Proust E, de Montfort A, Tang M, Mari K, Hopfer R, Gallichan S, Brookes RH. Ochs MM, et al. Hum Vaccin Immunother. 2016 Nov;12(11):2946-2952. doi: 10.1080/21645515.2016.1202389. Hum Vaccin Immunother. 2016. PMID: 27392182 Free PMC article. Clinical Trial.
39 results