The ability of an oligomeric human immunodeficiency virus type 1 (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable region.
Barnett SW, Lu S, Srivastava I, Cherpelis S, Gettie A, Blanchard J, Wang S, Mboudjeka I, Leung L, Lian Y, Fong A, Buckner C, Ly A, Hilt S, Ulmer J, Wild CT, Mascola JR, Stamatatos L.
Barnett SW, et al. Among authors: stamatatos l.
J Virol. 2001 Jun;75(12):5526-40. doi: 10.1128/JVI.75.12.5526-5540.2001.
J Virol. 2001.
PMID: 11356960
Free PMC article.
Partial deletion of the second hypervariable region from the envelope of the primary-like SF162 virus increases the exposure of certain neutralization epitopes and renders the virus, SF162DeltaV2, highly susceptible to neutralization by clade B and non-clade B human immunodeficie …
Partial deletion of the second hypervariable region from the envelope of the primary-like SF162 virus increases the exposure of certain neut …