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Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM. Sydow A, et al. Among authors: d hooge r, balschun d. J Neurosci. 2011 Feb 16;31(7):2511-25. doi: 10.1523/JNEUROSCI.5245-10.2011. J Neurosci. 2011. PMID: 21325519 Free PMC article.
Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model.
Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM. Sydow A, et al. Among authors: d hooge r, balschun d. J Mol Neurosci. 2011 Nov;45(3):432-7. doi: 10.1007/s12031-011-9604-5. Epub 2011 Aug 6. J Mol Neurosci. 2011. PMID: 21822709
Spred1 is required for synaptic plasticity and hippocampus-dependent learning.
Denayer E, Ahmed T, Brems H, Van Woerden G, Borgesius NZ, Callaerts-Vegh Z, Yoshimura A, Hartmann D, Elgersma Y, D'Hooge R, Legius E, Balschun D. Denayer E, et al. Among authors: d hooge r, balschun d. J Neurosci. 2008 Dec 31;28(53):14443-9. doi: 10.1523/JNEUROSCI.4698-08.2008. J Neurosci. 2008. PMID: 19118178 Free PMC article.
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean ME, Humez S, Balschun D, Blum D, Buée L, D'Hooge R. Van der Jeugd A, et al. Among authors: d hooge r, balschun d. Neurobiol Learn Mem. 2011 Mar;95(3):296-304. doi: 10.1016/j.nlm.2010.12.005. Epub 2010 Dec 16. Neurobiol Learn Mem. 2011. PMID: 21167950
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.
Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P. Prox J, et al. Among authors: d hooge r, balschun d. J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a. doi: 10.1523/JNEUROSCI.5910-12.2013. J Neurosci. 2013. PMID: 23926248 Free PMC article.
97 results