Zhang N - Search Results

1

Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.

D'Angelo ND, Kim TS, Andrews K, Booker SK, Caenepeel S, Chen K, D'Amico D, Freeman D, Jiang J, Liu L, McCarter JD, San Miguel T, Mullady EL, Schrag M, Subramanian R, Tang J, Wahl RC, Wang L, Whittington DA, Wu T, Xi N, Xu Y, Yakowec P, Yang K, Zalameda LP, Zhang N, Hughes P, Norman MH. D'Angelo ND, et al. Among authors: zhang n. J Med Chem. 2011 Mar 24;54(6):1789-811. doi: 10.1021/jm1014605. Epub 2011 Feb 18. J Med Chem. 2011. PMID: 21332118

2

Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles.

Boschelli DH, Wang YD, Ye F, Wu B, Zhang N, Dutia M, Powell DW, Wissner A, Arndt K, Weber JM, Boschelli F. Boschelli DH, et al. Among authors: zhang n. J Med Chem. 2001 Mar 1;44(5):822-33. doi: 10.1021/jm000420z. J Med Chem. 2001. PMID: 11262092

3

Discovery and evaluation of dual CDK1 and CDK2 inhibitors.

Payton M, Chung G, Yakowec P, Wong A, Powers D, Xiong L, Zhang N, Leal J, Bush TL, Santora V, Askew B, Tasker A, Radinsky R, Kendall R, Coats S. Payton M, et al. Among authors: zhang n. Cancer Res. 2006 Apr 15;66(8):4299-308. doi: 10.1158/0008-5472.CAN-05-2507. Cancer Res. 2006. PMID: 16618755

4

Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition.

Zhang N, Ayral-Kaloustian S, Nguyen T, Afragola J, Hernandez R, Lucas J, Gibbons J, Beyer C. Zhang N, et al. J Med Chem. 2007 Jan 25;50(2):319-27. doi: 10.1021/jm060717i. J Med Chem. 2007. PMID: 17228873

5

2-cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization.

Zhang N, Ayral-Kaloustian S, Nguyen T, Hernandez R, Beyer C. Zhang N, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3003-5. doi: 10.1016/j.bmcl.2007.03.070. Epub 2007 Mar 25. Bioorg Med Chem Lett. 2007. PMID: 17416524

6

Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents.

Zhang N, Ayral-Kaloustian S, Nguyen T, Hernandez R, Lucas J, Discafani C, Beyer C. Zhang N, et al. Bioorg Med Chem. 2009 Jan 1;17(1):111-8. doi: 10.1016/j.bmc.2008.11.016. Epub 2008 Nov 14. Bioorg Med Chem. 2009. PMID: 19041247

7

4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitors.

Zhang N, Wu B, Boschelli DH, Golas JM, Boschelli F. Zhang N, et al. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5071-4. doi: 10.1016/j.bmcl.2009.07.043. Epub 2009 Jul 10. Bioorg Med Chem Lett. 2009. PMID: 19632113

8

4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).

Tsou HR, MacEwan G, Birnberg G, Zhang N, Brooijmans N, Toral-Barza L, Hollander I, Ayral-Kaloustian S, Yu K. Tsou HR, et al. Among authors: zhang n. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2259-63. doi: 10.1016/j.bmcl.2010.02.012. Epub 2010 Feb 6. Bioorg Med Chem Lett. 2010. PMID: 20188551

9

5-ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-alpha and mTOR for the treatment of breast cancer.

Zhang N, Ayral-Kaloustian S, Anderson JT, Nguyen T, Das S, Venkatesan AM, Brooijmans N, Lucas J, Yu K, Hollander I, Mallon R. Zhang N, et al. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3526-9. doi: 10.1016/j.bmcl.2010.04.139. Epub 2010 May 17. Bioorg Med Chem Lett. 2010. PMID: 20483602

10

2-Aryl-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ols as a class of antitumor agents selectively active in securin(-/-) cells.

Zhang N, Ayral-Kaloustian S, Niu C, Nguyen T, Upeslacis E, Mansour TS, Ragunathan S, Rosfjord E. Zhang N, et al. Bioorg Med Chem Lett. 2010 Jul 1;20(13):3903-5. doi: 10.1016/j.bmcl.2010.05.021. Epub 2010 May 12. Bioorg Med Chem Lett. 2010. PMID: 20627558

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