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MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone.
Dujardin F, Binh MB, Bouvier C, Gomez-Brouchet A, Larousserie F, Muret Ad, Louis-Brennetot C, Aurias A, Coindre JM, Guillou L, Pedeutour F, Duval H, Collin C, de Pinieux G. Dujardin F, et al. Among authors: muret ad. Mod Pathol. 2011 May;24(5):624-37. doi: 10.1038/modpathol.2010.229. Epub 2011 Feb 18. Mod Pathol. 2011. PMID: 21336260 Free article.