Hersh LB - Search Results

1

Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism.

Song ES, Rodgers DW, Hersh LB. Song ES, et al. Among authors: hersh lb. J Biol Chem. 2011 Apr 22;286(16):13852-8. doi: 10.1074/jbc.M110.191668. Epub 2011 Feb 22. J Biol Chem. 2011. PMID: 21343292 Free PMC article.

2

Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates.

Song ES, Mukherjee A, Juliano MA, Pyrek JS, Goodman JP Jr, Juliano L, Hersh LB. Song ES, et al. Among authors: hersh lb. J Biol Chem. 2001 Jan 12;276(2):1152-5. doi: 10.1074/jbc.M008702200. J Biol Chem. 2001. PMID: 11042190 Free article.

3

ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety.

Song ES, Juliano MA, Juliano L, Fried MG, Wagner SL, Hersh LB. Song ES, et al. Among authors: hersh lb. J Biol Chem. 2004 Dec 24;279(52):54216-20. doi: 10.1074/jbc.M411177200. Epub 2004 Oct 19. J Biol Chem. 2004. PMID: 15494400 Free article.

4

Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions.

Song ES, Daily A, Fried MG, Juliano MA, Juliano L, Hersh LB. Song ES, et al. Among authors: hersh lb. J Biol Chem. 2005 May 6;280(18):17701-6. doi: 10.1074/jbc.M501896200. Epub 2005 Mar 3. J Biol Chem. 2005. PMID: 15749695 Free article.

5

Insulysin: an allosteric enzyme as a target for Alzheimer's disease.

Song ES, Hersh LB. Song ES, et al. Among authors: hersh lb. J Mol Neurosci. 2005;25(3):201-6. doi: 10.1385/JMN:25:3:201. J Mol Neurosci. 2005. PMID: 15800373

6

Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation.

Song ES, Cady C, Fried MG, Hersh LB. Song ES, et al. Among authors: hersh lb. Biochemistry. 2006 Dec 19;45(50):15085-91. doi: 10.1021/bi061298u. Biochemistry. 2006. PMID: 17154546 Free PMC article.

7

A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties.

Song ES, Rodgers DW, Hersh LB. Song ES, et al. Among authors: hersh lb. PLoS One. 2010 Mar 16;5(3):e9719. doi: 10.1371/journal.pone.0009719. PLoS One. 2010. PMID: 20300529 Free PMC article.

8

Anion activation site of insulin-degrading enzyme.

Noinaj N, Song ES, Bhasin S, Alper BJ, Schmidt WK, Hersh LB, Rodgers DW. Noinaj N, et al. Among authors: hersh lb. J Biol Chem. 2012 Jan 2;287(1):48-57. doi: 10.1074/jbc.M111.264614. Epub 2011 Nov 2. J Biol Chem. 2012. PMID: 22049080 Free PMC article.

9

Active site mutations change the cleavage specificity of neprilysin.

Sexton T, Hitchcook LJ, Rodgers DW, Bradley LH, Hersh LB. Sexton T, et al. Among authors: hersh lb. PLoS One. 2012;7(2):e32343. doi: 10.1371/journal.pone.0032343. Epub 2012 Feb 23. PLoS One. 2012. PMID: 22384224 Free PMC article.

10

Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation.

Song ES, Melikishvili M, Fried MG, Juliano MA, Juliano L, Rodgers DW, Hersh LB. Song ES, et al. Among authors: hersh lb. PLoS One. 2012;7(10):e46790. doi: 10.1371/journal.pone.0046790. Epub 2012 Oct 15. PLoS One. 2012. PMID: 23077523 Free PMC article.

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