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Page 1
SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei.
Perales JB, Freeman J, Bacchi CJ, Bowling T, Don R, Gaukel E, Mercer L, Moore JA 3rd, Nare B, Nguyen TM, Noe RA, Randolph R, Rewerts C, Wring SA, Yarlett N, Jacobs RT. Perales JB, et al. Among authors: freeman j. Bioorg Med Chem Lett. 2011 May 15;21(10):2816-9. doi: 10.1016/j.bmcl.2011.03.097. Epub 2011 Apr 1. Bioorg Med Chem Lett. 2011. PMID: 21507639
Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.
Zhao G, Souers AJ, Voorbach M, Falls HD, Droz B, Brodjian S, Lau YY, Iyengar RR, Gao J, Judd AS, Wagaw SH, Ravn MM, Engstrom KM, Lynch JK, Mulhern MM, Freeman J, Dayton BD, Wang X, Grihalde N, Fry D, Beno DW, Marsh KC, Su Z, Diaz GJ, Collins CA, Sham H, Reilly RM, Brune ME, Kym PR. Zhao G, et al. Among authors: freeman j. J Med Chem. 2008 Feb 14;51(3):380-3. doi: 10.1021/jm7013887. Epub 2008 Jan 10. J Med Chem. 2008. PMID: 18183944
An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists.
Iyengar RR, Lynch JK, Mulhern MM, Judd AS, Freeman JC, Gao J, Souers AJ, Zhao G, Wodka D, Doug Falls H, Brodjian S, Dayton BD, Reilly RM, Swanson S, Su Z, Martin RL, Leitza ST, Houseman KA, Diaz G, Collins CA, Sham HL, Kym PR. Iyengar RR, et al. Among authors: freeman jc. Bioorg Med Chem Lett. 2007 Feb 15;17(4):874-8. doi: 10.1016/j.bmcl.2006.11.065. Epub 2006 Dec 1. Bioorg Med Chem Lett. 2007. PMID: 17234405
Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors.
Liu G, Lynch JK, Freeman J, Liu B, Xin Z, Zhao H, Serby MD, Kym PR, Suhar TS, Smith HT, Cao N, Yang R, Janis RS, Krauser JA, Cepa SP, Beno DW, Sham HL, Collins CA, Surowy TK, Camp HS. Liu G, et al. Among authors: freeman j. J Med Chem. 2007 Jun 28;50(13):3086-100. doi: 10.1021/jm070219p. Epub 2007 May 27. J Med Chem. 2007. PMID: 17530838
Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists.
Kym PR, Iyengar R, Souers AJ, Lynch JK, Judd AS, Gao J, Freeman J, Mulhern M, Zhao G, Vasudevan A, Wodka D, Blackburn C, Brown J, Che JL, Cullis C, Lai SJ, LaMarche MJ, Marsilje T, Roses J, Sells T, Geddes B, Govek E, Patane M, Fry D, Dayton BD, Brodjian S, Falls D, Brune M, Bush E, Shapiro R, Knourek-Segel V, Fey T, McDowell C, Reinhart GA, Preusser LC, Marsh K, Hernandez L, Sham HL, Collins CA. Kym PR, et al. Among authors: freeman j. J Med Chem. 2005 Sep 22;48(19):5888-91. doi: 10.1021/jm050598r. J Med Chem. 2005. PMID: 16161992
State of the Art in Left Atrial Appendage Occlusion.
Garg J, Kabra R, Gopinathannair R, Di Biase L, Wang DD, Saw J, Hahn R, Freeman JV, Ellis CR, Lakkireddy D. Garg J, et al. Among authors: freeman jv. JACC Clin Electrophysiol. 2024 Dec 31:S2405-500X(24)00932-0. doi: 10.1016/j.jacep.2024.10.024. Online ahead of print. JACC Clin Electrophysiol. 2024. PMID: 39797854 Review.
Commutability assessment of new standard reference materials (SRMs) for determining serum total 25-hydroxyvitamin D using ligand binding and liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays.
Wise SA, Cavalier É, Lukas P, Peeters S, Le Goff C, Briggs LE, Williams EL, Mineva E, Pfeiffer CM, Vesper H, Popp C, Beckert C, Schultess J, Wang K, Tourneur C, Pease C, Osterritter D, Fischer R, Saida B, Dou C, Kojima S, Weiler HA, Bielecki A, Pham H, Bennett A, You S, Ghoshal AK, Wei B, Vogl C, Freeman J, Parker N, Pagliaro S, Cheek J, Li J, Tsukamoto H, Galvin K, Cashman KD, Liao HC, Hoofnagle AN, Budd JR, Kuszak AJ, Boggs ASP, Burdette CQ, Hahm G, Nalin F, Camara JE. Wise SA, et al. Among authors: freeman j. Anal Bioanal Chem. 2025 Jan 10. doi: 10.1007/s00216-024-05699-7. Online ahead of print. Anal Bioanal Chem. 2025. PMID: 39789379
Cognitive Behavioral Therapy and Biofeedback.
Wie C, Dunn T, Sperry J, Strand N, Dawodu A, Freeman J, Covington S, Pew S, Misra L, Maloney J. Wie C, et al. Among authors: freeman j. Curr Pain Headache Rep. 2025 Jan 9;29(1):23. doi: 10.1007/s11916-024-01348-x. Curr Pain Headache Rep. 2025. PMID: 39786604 Review.
4,549 results