Greenbaum DC - Search Results

1

Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Velmourougane G, Harbut MB, Dalal S, McGowan S, Oellig CA, Meinhardt N, Whisstock JC, Klemba M, Greenbaum DC. Velmourougane G, et al. Among authors: greenbaum dc. J Med Chem. 2011 Mar 24;54(6):1655-66. doi: 10.1021/jm101227t. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366301 Free PMC article.

2

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.

Harbut MB, Velmourougane G, Dalal S, Reiss G, Whisstock JC, Onder O, Brisson D, McGowan S, Klemba M, Greenbaum DC. Harbut MB, et al. Among authors: greenbaum dc. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E526-34. doi: 10.1073/pnas.1105601108. Epub 2011 Aug 15. Proc Natl Acad Sci U S A. 2011. PMID: 21844374 Free PMC article.

3

Development of bestatin-based activity-based probes for metallo-aminopeptidases.

Harbut MB, Velmourougane G, Reiss G, Chandramohanadas R, Greenbaum DC. Harbut MB, et al. Among authors: greenbaum dc. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5932-6. doi: 10.1016/j.bmcl.2008.09.021. Epub 2008 Sep 10. Bioorg Med Chem Lett. 2008. PMID: 18823778 Free PMC article.

4

Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells.

Chandramohanadas R, Davis PH, Beiting DP, Harbut MB, Darling C, Velmourougane G, Lee MY, Greer PA, Roos DS, Greenbaum DC. Chandramohanadas R, et al. Among authors: greenbaum dc. Science. 2009 May 8;324(5928):794-7. doi: 10.1126/science.1171085. Epub 2009 Apr 2. Science. 2009. PMID: 19342550 Free PMC article.

5

Development of α-helical calpain probes by mimicking a natural protein-protein interaction.

Jo H, Meinhardt N, Wu Y, Kulkarni S, Hu X, Low KE, Davies PL, DeGrado WF, Greenbaum DC. Jo H, et al. Among authors: greenbaum dc. J Am Chem Soc. 2012 Oct 24;134(42):17704-13. doi: 10.1021/ja307599z. Epub 2012 Oct 11. J Am Chem Soc. 2012. PMID: 22998171 Free PMC article.

6

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Mallari JP, et al. J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173229

7

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.

Harbut MB, Patel BA, Yeung BK, McNamara CW, Bright AT, Ballard J, Supek F, Golde TE, Winzeler EA, Diagana TT, Greenbaum DC. Harbut MB, et al. Among authors: greenbaum dc. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21486-91. doi: 10.1073/pnas.1216016110. Epub 2012 Dec 11. Proc Natl Acad Sci U S A. 2012. PMID: 23236186 Free PMC article.

8

Thioamide-based fluorescent protease sensors.

Goldberg JM, Chen X, Meinhardt N, Greenbaum DC, Petersson EJ. Goldberg JM, et al. Among authors: greenbaum dc. J Am Chem Soc. 2014 Feb 5;136(5):2086-93. doi: 10.1021/ja412297x. Epub 2014 Jan 28. J Am Chem Soc. 2014. PMID: 24472041 Free PMC article.

9

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Greenbaum DC, et al. J Med Chem. 2004 Jun 3;47(12):3212-9. doi: 10.1021/jm030549j. J Med Chem. 2004. PMID: 15163200

10

Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

Lucumi E, Darling C, Jo H, Napper AD, Chandramohanadas R, Fisher N, Shone AE, Jing H, Ward SA, Biagini GA, DeGrado WF, Diamond SL, Greenbaum DC. Lucumi E, et al. Among authors: greenbaum dc. Antimicrob Agents Chemother. 2010 Sep;54(9):3597-604. doi: 10.1128/AAC.00431-10. Epub 2010 Jun 14. Antimicrob Agents Chemother. 2010. PMID: 20547797 Free PMC article.

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