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Hydroxyurea (HU) is effective in reducing JAK2V617F mutated clone size in the peripheral blood of essential thrombocythemia (ET) and polycythemia vera (PV) patients.
Spanoudakis E, Bazdiara I, Kotsianidis I, Margaritis D, Goutzouvelidis A, Christoforidou A, Tsatalas C, Bourikas G. Spanoudakis E, et al. Among authors: goutzouvelidis a. Ann Hematol. 2009 Jul;88(7):629-32. doi: 10.1007/s00277-008-0650-1. Epub 2008 Dec 19. Ann Hematol. 2009. PMID: 19096846 Clinical Trial.
Hydroxyurea and anagrelide combination therapy in patients with chronic myeloproliferative diseases resistant or intolerant to monotherapy.
Christoforidou A, Pantelidou D, Anastasiadis A, Goutzouvelidis A, Margaritis D, Kotsianidis I, Spanoudakis E, Kaloutsi V, Bourikas G, Tsatalas C. Christoforidou A, et al. Among authors: goutzouvelidis a. Acta Haematol. 2008;120(4):195-8. doi: 10.1159/000189381. Epub 2009 Jan 8. Acta Haematol. 2008. PMID: 19129692 No abstract available.